Using two ways of functionalizing amiridine—acylation with chloroacetic acid chloride and
reaction with thiophosgene—we have synthesized new homobivalent bis-amiridines joined …

The number of patients with neurodegenerative diseases, particularly Alzheimer's disease
(AD), continues to grow yearly. Cholinesterase inhibitors (ChEIs) represent the first-line …

Alzheimer's disease (AD) is a multifactorial neurodegenerative process whose effective
treatment will require drugs that can act simultaneously on multiple pathogenic targets …

Alzheimer's disease is debilitating neurodegenerative disorder in the elderly. Current
therapy relies on administration of acetylcholinesterase inhibitors (AChEIs)-donepezil …

Berberine, a naturally occurring compound, possesses an interesting multipotent
pharmacological profile potentially applicable for Alzheimer's disease (AD) treatment. In this …

Alzheimer's disease (AD) is a serious threat to the global health care system and is brought
on by a series of factors that cause neuronal dysfunction and impairment in memory and …

Twelve derivatives 1a–1m of the β-crinane-type alkaloid haemanthamine were developed.
All the semisynthetic derivatives were studied for their inhibitory potential against both …

The amyloid precursor protein (APP) and acetylcholinesterase (AChE) are multi-faceted
proteins with a wide range of vital functions, both crucially linked with the pathogenesis of …

A total of 20 derivatives (1–20) of the crinane-type alkaloid ambelline were synthesized.
These semisynthetic derivatives were assessed for their potency to inhibit both …

A novel series of 6-chlorotacrine-scutellarin hybrids was designed, synthesized and the
biological activity as potential anti-Alzheimer's agents was assessed. Their inhibitory activity …