[HTML][HTML] Sex differences in autoimmune diseases

R Voskuhl - Biology of sex differences, 2011 - Springer
Women are more susceptible to a variety of autoimmune diseases including systemic lupus
erythematosus (SLE), multiple sclerosis (MS), primary biliary cirrhosis, rheumatoid arthritis …

Metabolic syndrome

TS Han, MEJ Lean - Medicine, 2015 - Elsevier
The metabolic syndrome is a condition characterized by the co-existence of several major
risk factors for cardiovascular disease (CVD)–high blood pressure, hyperglycaemia, and …

[HTML][HTML] Estrogen alleviates neuropathic pain induced after spinal cord injury by inhibiting microglia and astrocyte activation

JY Lee, HY Choi, BG Ju, TY Yune - … Acta (BBA)-Molecular Basis of Disease, 2018 - Elsevier
Neuropathic pain after spinal cord injury (SCI) is developed in about 80% of SCI patients
and there is no efficient therapeutic drug to alleviate SCI-induced neuropathic pain. Here we …

Estrogen and testosterone therapies in multiple sclerosis

SM Gold, RR Voskuhl - Progress in brain research, 2009 - Elsevier
It has been known for decades that females are more susceptible than men to inflammatory
autoimmune diseases, including multiple sclerosis (MS), rheumatoid arthritis, and psoriasis …

Differential neuroprotective and antiinflammatory effects of estrogen receptor (ER) α and ERβ ligand treatment

S Tiwari-Woodruff, LBJ Morales… - Proceedings of the …, 2007 - National Acad Sciences
Treatment with either estradiol or an estrogen receptor (ER) α ligand has been shown to be
both antiinflammatory and neuroprotective in a variety of neurological disease models, but …

Estrogen attenuated markers of inflammation and decreased lesion volume in acute spinal cord injury in rats

EA Sribnick, JM Wingrave, DD Matzelle… - Journal of …, 2005 - Wiley Online Library
Spinal cord injury (SCI) is a devastating neurologic injury with functional deficits for which
the only currently recommended pharmacotherapy is high‐dose methylprednisolone, which …

Treatment with an estrogen receptor α ligand is neuroprotective in experimental autoimmune encephalomyelitis

LBJ Morales, KK Loo, H Liu, C Peterson… - Journal of …, 2006 - Soc Neuroscience
Multiple sclerosis is an inflammatory, neurodegenerative disease for which experimental
autoimmune encephalomyelitis (EAE) is a model. Treatments with estrogens have been …

Estrogen treatment in multiple sclerosis

SM Gold, RR Voskuhl - Journal of the neurological sciences, 2009 - Elsevier
Currently available treatments for multiple sclerosis (MS) reduce inflammatory lesions on
MRI and decrease clinical relapses but have limited effects on disability. Novel treatment …

Chondroitinase ABC improves basic and skilled locomotion in spinal cord injured cats

NJ Tester, DR Howland - Experimental neurology, 2008 - Elsevier
Chondroitin sulfate proteoglycans (CSPGs) are upregulated in the central nervous system
following injury. Chondroitin sulfate glycosaminoglycan (CS GAG) side chains substituted on …

Female rats demonstrate improved locomotor recovery and greater preservation of white and gray matter after traumatic spinal cord injury compared to males

JP Datto, JC Bastidas, NL Miller, AK Shah… - Journal of …, 2015 - liebertpub.com
The possibility of a gender-related difference in recovery after spinal cord injury (SCI)
remains a controversial subject. Current empirical animal research lacks sizable test groups …