Inflammation is associated with DNA damage, cellular senescence, and aging. Cessation of
the inflammatory cytokine response is mediated in part through cytokine mRNA degradation …

Aging attenuates the overall responsiveness of the immune system to eradicate pathogens.
The increased production of pro-inflammatory cytokines by innate immune cells under basal …

The RNA-binding protein HuR is highly abundant in many cancers. HuR expression was
recently found to be repressed by microRNA miR-519, which potently lowered HuR …

Neuronal development and plasticity are maintained by tightly regulated gene expression
programs. Here, we report that the developmentally regulated microRNA miR-375 affects …

The levels of microRNAs (miRNAs) are altered under different conditions such as cancer,
senescence, and aging. Here, we have identified differentially expressed miRNAs in skeletal …

In response to different stress stimuli, cells transiently form stress granules (SGs) in order to
protect themselves and re-establish homeostasis. Besides these important cellular functions …

The ubiquitously expressed RNA-binding protein HuR increases the stability and translation
of mRNAs encoding growth regulatory proteins that promote proliferation in a variety of cell …

Aging represents the major risk factor for the onset and/or progression of various disorders
including neurodegenerative diseases, metabolic disorders, and bone-related defects. As …

A number of neurologic diseases associated with expanded nucleotide repeats, including
an inherited form of amyotrophic lateral sclerosis, have an unconventional form of translation …

Aging is a process during which progressive deteriorating of cells, tissues, and organs over
time lead to loss of function, disease, and death. Towards the goal of extending human …