Physiological networks and disease functions of RNA‐binding protein AUF1

AE Moore, DM Chenette, LC Larkin… - Wiley Interdisciplinary …, 2014 - Wiley Online Library
Regulated messenger RNA (mRNA) decay is an essential mechanism that governs proper
control of gene expression. In fact, many of the most physiologically potent proteins are …

RNA binding proteins in the regulation of heart development

Y Blech-Hermoni, AN Ladd - The international journal of biochemistry & …, 2013 - Elsevier
In vivo, RNA molecules are constantly accompanied by RNA binding proteins (RBPs), which
are intimately involved in every step of RNA biology, including transcription, editing, splicing …

T-cell intracellular antigen 1-like protein in physiology and pathology

BR Velasco, JM Izquierdo - International Journal of Molecular Sciences, 2022 - mdpi.com
T-cell intracellular antigen 1 (TIA1)-related/like (TIAR/TIAL1) protein is a multifunctional RNA-
binding protein (RBP) involved in regulating many aspects of gene expression …

T-cell intracellular antigens in health and disease

C Sánchez-Jiménez, JM Izquierdo - Cell Cycle, 2015 - Taylor & Francis
T-cell intracellular antigen 1 (TIA1) and TIA1-related/like protein (TIAR/TIAL1) are 2 proteins
discovered in 1991 as components of cytotoxic T lymphocyte granules. They act in the …

Tristetraprolin: roles in cancer and senescence

CR Ross, SE Brennan-Laun, GM Wilson - Ageing research reviews, 2012 - Elsevier
Cancer and senescence are both complex transformative processes that dramatically alter
many features of cell physiology and their interactions with surrounding tissues. Developing …

Mitochondrion-mediated cell death through Erk1-Alox5 Independent of Caspase-9 signaling

M Chen, L Wang, M Li, MM Budai, J Wang - Cells, 2022 - mdpi.com
Mitochondrial disruption leads to the release of cytochrome c to activate caspase-9 and the
downstream caspase cascade for the execution of apoptosis. However, cell death can …

Characterization of hibernating ribosomes in mammalian cells

D Krokowski, F Gaccioli, M Majumder, MR Mullins… - Cell cycle, 2011 - Taylor & Francis
Protein synthesis across kingdoms involves the assembly of 70S (prokaryotes) or 80S
(eukaryotes) ribosomes on the mRNAs to be translated. 70S ribosomes are protected from …

CASowary: CRISPR-Cas13 guide RNA predictor for transcript depletion

A Krohannon, M Srivastava, S Rauch, R Srivastava… - BMC genomics, 2022 - Springer
Background Recent discovery of the gene editing system-CRISPR (Clustered Regularly
Interspersed Short Palindromic Repeats) associated proteins (Cas), has resulted in its …

The miR-30-5p/TIA-1 axis directs cellular senescence by regulating mitochondrial dynamics

H Tak, S Cha, Y Hong, M Jung, S Ryu, S Han… - Cell Death & …, 2024 - nature.com
Senescent cells exhibit a diverse spectrum of changes in their morphology, proliferative
capacity, senescence-associated secretory phenotype (SASP) production, and …

The RNA-binding protein, ZFP36L2, influences ovulation and oocyte maturation

CB Ball, KF Rodriguez, DJ Stumpo, F Ribeiro-Neto… - PloS one, 2014 - journals.plos.org
ZFP36L2 protein destabilizes AU-rich element-containing transcripts and has been
implicated in female fertility. In the C57BL/6NTac mouse, a mutation in Zfp36l2 that results in …