The immune response is critical for the elimination of pathogens. However, uncontrolled
immune responses can lead to tissue damage and inflammatory diseases. The generation …

Allison B. Herman and Michael V. Autieri www. aging-us. com AGING 2018, Vol. 10, No. 11
www. aging-us. com 3046 AGING neuronal protein, and a presumed mRNA-binding protein …

The potassium voltage-gated channel subfamily H member 2 (KCNH2) gene encodes the
Kv11. 1 potassium channel, which conducts the rapidly activating delayed rectifier current in …

Mammalian T7 polymerase-based cytoplasmic expression systems are common tool for
molecular studies. The majority of these systems include the internal ribosome entry site …

Enrichment of production yield of therapeutic proteins in mammalian cell cultures by
modulation of the m RNA stability of the target protein to increase its in vivo half‐life is a new …

Several AU-rich RNA binding element (ARE) proteins were investigated for their possible
effects on transcription of hepatic 3-hydroxy-3-methyglutaryl coenzyme A reductase (HMGR) …

Alternative splicing (AS) is a feature of most multi-exonic human genes and its dysregulation
is known to contribute to ageing and disease. However, the genome-wide accuracy of AS …

The nucleolus is a dynamic structure where ribosome subunits are produced. Indeed,
nucleoli respond to any change in cellular homeostasis by altering the rate of ribosome …

Tristetraprolin (TTP), an RNA-binding protein, controls the stability of RNA by capturing AU-
rich elements on their target genes. It has recently been identified that TTP serves as an anti …

T-cell intracellular antigen 1 (TIA1)-related/like (TIAR/TIAL1) protein is a multifunctional RNA-
binding protein (RBP) involved in regulating many aspects of gene expression …