The intestinal epithelium is a multicellular interface in close proximity to a dense microbial
milieu that is completely renewed every 3–5 days. Pluripotent stem cells reside at the crypt …

In 1999, Genes and Immunity published a systematic review and on-line database of
cytokine gene polymorphism in human disease, 1 and in 2001 a supplement to the review …

Inflammatory bowel disease (IBD) typically manifests as either ulcerative colitis (UC) or
Crohn's disease (CD). Systematic identification of susceptibility genes for IBD has thus far …

There is strong evidence that genetic as well as environmental factors affect the
development of periodontitis, and some suggestion that aggressive and chronic forms of the …

Inflammatory bowel diseases (IBD) such as Crohn's disease (CD) or ulcerative colitis are
chronic intestinal disorders, which are on the increase in “Westernised” countries. IBD can …

The spleen regulatory B cell subset with the functional capacity to express IL-10 (B10 cells)
modulates both immune responses and autoimmune disease severity. However, the …

The pathogenesis of inflammatory bowel disease (IBD) is only partially understood. Various
environmental and host (eg genetic-, epithelial-, immune and non-immune) factors are …

IL-10 is a potent anti-inflammatory cytokine capable of suppressing a number of
proinflammatory signals associated with intestinal inflammatory diseases, such as ulcerative …

Interleukin (IL)-10 has important effects in immunoregulation and inflammation, and previous
studies have provided evidence for the involvement of IL-10 in the pathogenesis of Crohn's …

Necrotizing enterocolitis (NEC) is the leading intestinal emergency in premature infants. The
underlying etiology of NEC remains elusive, but hypoxic conditions and early enteral …