Considering the substantial role played by dendritic cells (DCs) in the immune system to
bridge innate and adaptive immunity, studies on DC-mediated immunity toward biomaterials …

The development of nanomaterials to induce antigen-specific immune tolerance has shown
promise for treating autoimmune diseases. While PEGylation has been widely used to …

The foreign body response (FBR) remains a clinical challenge in the field of biomaterials
due to its ability to elicit a chronic and sustained immune response. Modulating the immune …

Tendon injuries are at the frontier of innovative approaches to public health concerns and
sectoral policy objectives. Indeed, these injuries remain difficult to manage due to tendon's …

Immune homeostasis is maintained by a precise balance between effector immune cells and
regulatory immune cells. Chronic deviations from immune homeostasis, driven by a greater …

The immune system has remarkable capabilities to combat disease with exquisite selectivity.
This feature has enabled vaccines that provide protection for decades and, more recently …

Lymph nodes (LNs) are at the cross roads of immunity and tolerance. These tissues are
compartmentalized into specialized niche areas by lymph node stromal cells (LN SCs). LN …

Systemic immunosuppression for the mitigation of immune rejection after organ
transplantation causes adverse side effects and constrains the long-term benefits of the …

During autoimmunity or organ transplant rejection, the immune system attacks host or
transplanted tissue, causing debilitating inflammation for millions of patients. There is no …

Immunotherapies are an evolving treatment paradigm for addressing cancer, autoimmunity,
and infection. While exciting, most of the existing therapies are limited by their specificity─ …