Designing biomaterials for the treatment of autoimmune diseases

B Tang, X Xie, J Lu, W Huang, J Yang, J Tian… - Applied Materials …, 2024 - Elsevier
Autoimmune diseases (ADs) are a group of chronic relapsing inflammatory diseases that
cause great suffering to patients and increase the economic burden of society. However, the …

Immunoengineering has arrived

JJ Green - Journal of Biomedical Materials Research Part A, 2021 - Wiley Online Library
Immunoengineering is a new discipline that creates and applies engineering tools and
principles to investigate and modulate the immune system. It spans from the molecular scale …

New therapeutic approaches for allergy: A review of cell therapy and bio-or nano-material-based strategies

JL Paris, P de la Torre, AI Flores - Pharmaceutics, 2021 - mdpi.com
Allergy constitutes a major health issue due to its large prevalence. The established
therapeutic approaches (allergen avoidance, antihistamines, and corticosteroids) do not …

ABCD of IA: A multi-scale agent-based model of T cell activation in inflammatory arthritis

DA McBride, JS Wang, WT Johnson, N Bottini… - Biomaterials …, 2024 - pubs.rsc.org
Biomaterial-based agents have been demonstrated to regulate the function of immune cells
in models of autoimmunity. However, the complexity of the kinetics of immune cell activation …

Biomaterials for topical and transdermal drug delivery in reconstructive transplantation

A Dhayani, S Kalita, M Mahato, P Srinath… - Nanomedicine, 2019 - Future Medicine
Lifelong systemic immunosuppression remains the biggest challenge in vascularized
composite allotransplantation (VCA) due to the adverse effects it causes. Since VCA is a life …

Targeting lymphoid tissues to promote immune tolerance

XY Chen, GS Du, X Sun - Advanced Therapeutics, 2021 - Wiley Online Library
The enormous research progress in autoimmune disorders makes the establishment of long‐
term clinical tolerance to autoantigens an accessible goal. This strategy endows lymphoid …

Engineering strategies for allogeneic solid tissue acceptance

AR Sousa, JF Mano, MB Oliveira - Trends in Molecular Medicine, 2021 - cell.com
Advances in allogeneic transplantation of solid organs and tissues depend on our
understanding of mechanisms that mediate the prevention of graft rejection. For the past …

The Biocomplex Assembled from Antigen Peptide and Toll‐like Receptor Agonist Improved the Immunity against Pancreatic Adenocarcinoma In Vivo

W Feng, H Yu, T Xue, C Wu, F Ren… - Journal of Oncology, 2022 - Wiley Online Library
Purpose. One of the biggest challenges in cancer immunotherapy is generating robust
cancer‐specific immunity. This work describes using a biocomplex assembled from a toll …

[PDF][PDF] Scaffold-mediated immunoengineering as innovative strategy for tendon regeneration. Cells. 2022; 11: 266

V Russo, M El Khatib, G Prencipe, A Cerveró-Varona… - 2022 - researchgate.net
Tendon injuries are at the frontier of innovative approaches to public health concerns and
sectoral policy objectives. Indeed, these injuries remain difficult to manage due to tendon's …

Biomaterials as tools for re-balancing skewed immunity in rheumatoid arthritis

P Zhang, H Jia - Translational Autoimmunity, 2023 - Elsevier
Rheumatoid arthritis (RA) is a systemic autoimmune disease featured by skewed immunity
that can cause joint inflammation and cartilage destruction. Existing clinical therapeutic …