Vascular endothelial growth factor-A (VEGF-A) is a key mediator of angiogenesis, signalling
via the class IV tyrosine kinase receptor family of VEGF Receptors (VEGFRs). Although …

Adaptable hydrogels have recently emerged as a promising platform for three‐dimensional
(3D) cell encapsulation and culture. In conventional, covalently crosslinked hydrogels …

Stroke is the primary cause of disability due to the brain's limited ability to regenerate
damaged tissue. After stroke, an increased inflammatory and immune response coupled …

Enabling angiogenesis is critical for the success of tissue repair therapies and the fate of
tissue-engineered constructs. Although many biochemical signaling molecules have been …

Aptamers are oligonucleotide ligands that are selected for high-affinity binding to molecular
targets. Pegaptanib sodium (Macugen; Eyetech Pharmaceuticals/Pfizer) is an RNA aptamer …

Vascular endothelial growth factors (VEGFs) are a family of secreted polypeptides with a
highly conserved receptor-binding cystine-knot structure similar to that of the platelet-derived …

Vascular endothelial growth factor (VEGF) is a secreted mitogen highly specific for cultured
endothelial cells. In vivo VEGF induces microvascular permeability and plays a central role …

The extracellular matrix (ECM) provides cells with positional information and a mechanical
scaffold for adhesion and migration. It consists of collagens, glycoproteins, proteoglycans …

The physiology of microvessels limits the growth and development of tumours. Tumours gain
nutrients and excrete waste through growth-associated microvessels. New anticancer …

Angiogenesis inhibitors are receiving increased attention as cancer therapeutics, but little is
known of the cellular effects of these inhibitors on tumor vessels. We sought to determine …