Abstract Cisplatin or (SP-4-2)-diamminedichloridoplatinum (II) is one of the most potential
and widely used drugs for the treatment of various solid cancers such as testicular, ovarian …

Ovarian cancer (OC) is one of the most common gynecologic tumors worldwide and one
with the highest mortality. Cisplatin (DDP) is the first platinum-based complex approved by …

Elevated intracellular reactive oxygen species (ROS) and antioxidant defense systems have
been recognized as one of the hallmarks of cancer cells. Compared with normal cells …

Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …

The treatment of advanced non-small cell lung cancer (NSCLC) may be changing, but the
cisplatin-based doublet remains the foundation of treatment for the majority of patients with …

Cancer is a major threat to human health. Among various treatment methods, precision
therapy has received significant attention since the inception, due to its ability to efficiently …

Metals are essential cellular components selected by nature to function in several
indispensable biochemical processes for living organisms. Metals are endowed with unique …

The study of metal complexes for the treatment of cancer diseases has resulted in the
identification of some unique properties of ruthenium-based compounds. Among these …

Biochemical modulation is the manipulation of cellular biochemical pathways by chemical
agents to produce selective enhancement of the efficacy of an antitumor drug. 1 Since the …

Research in the field of bioinorganic chemistry has been stimulated by the worldwide
success of the anticancer drug cisplatin. 40 years after the first report about its biological …