Substance P (SP) is one of the most abundant peptides in the central nervous system and
has been implicated in a variety of physiological and pathophysiological processes …

In recent years, studies have advocated neuropeptide systems as modulators for the
behavioral states found in mood disorders such as depression and anxiety disorders …

Withdrawal anxiety is a significant factor contributing to continued alcohol abuse in
alcoholics. This anxiety is long-lasting, can manifest well after the overt physical symptoms …

The basolateral amygdala (BL) is a putative site for regulating anxiety, where inhibition and
excitation respectively lead to decreases and increases in anxiety-like behaviors. The BL …

Substance P (SP) is an 11-amino acid neuropeptide of the tachykinin family that
preferentially activates the neurokinin-1 receptor (NK1R). First isolated 85 years ago and …

Increasing evidence suggests that substance P (SP) and its receptor (neurokinin [NK]-1
receptor [NK1R]) might play an important role in the modulation of stress-related, affective …

For decades, research has demonstrated that chronic diseases characterized by
dysregulation of inflammation are particularly susceptible to exacerbation by stress and …

Marked species differences in the distribution of central tachykinin receptors are reported but
uncertainty remains about the ability of available ligands to detect NK2 and NK3 receptors in …

Research on Substance P (SP) has, until recently, focused on its role in pain and
inflammation. However, a report that NK1 receptor antagonists have utility in the treatment of …

The peptide substance P and its tachykinin receptor, neurokinin-1 (NK1), have been the
focus of considerable research for their role in a variety of both central and peripheral …