Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with progressive
paralysis of limbs and bulb in patients, the cause of which remains unclear. Accumulating …

The available medications for the treatment of major depressive disorder have limitations,
particularly their limited efficacy, delayed therapeutic effects, and the side effects associated …

Atorvastatin has been shown to exert a neuroprotective action by counteracting
glutamatergic toxicity. Recently, we have shown atorvastatin also exerts an antidepressant …

Guanosine (GUO) has been shown to act as a neuroprotective agent against glutamatergic
excitotoxicity by increasing glutamate uptake and decreasing its release. In this study, a …

Mood disorders are associated with significant psychosocial and occupational disability. It is
estimated that major depressive disorder (MDD) will become the second leading cause of …

Alzheimer's disease (AD) is a progressive neurodegenerative illness responsible for
cognitive impairment and dementia. Accumulation of amyloid-beta (Aβ) peptides in neurons …

Over the years, increasing data concerning the extracellular effect of guanine-based purines
have been published. This class of molecules that embraces the well-known nucleotides …

Guanosine has been reported to elicit antidepressant-like responses in rodents, but if these
actions are associated with its ability to afford neuroprotection against glutamate-induced …

Background Glutamate-induced neuronal cell death plays a key role in neurodegenerative
diseases such as Alzheimer's and Parkinson's diseases. Some recent studies reported the …

Guanosine, the endogenous guanine nucleoside, prevents cellular death induced by
ischemic events and is a promising neuroprotective agent. During an ischemic event, nitric …