Turnover of nucleoplasmic transcripts by the mammalian multi-subunit RNA exosome is
mediated by two adaptors: the Nuclear EXosome Targeting (NEXT) complex and the Poly …

Nanostructured devices and nanoparticles have fundamentally reshaped the development
of precision healthcare in recent decades. Meanwhile, mass spectrometry (MS)-based …

The N-methyl-d-aspartate (NMDA) receptor is a glutamate-activated cation channel that is
critical to many processes in the brain. Genome-wide association studies suggest that …

Membrane-bound particles in plasma are composed of exosomes, microvesicles, and
apoptotic bodies and represent~ 1–2% of the total protein composition. Proteomic …

Recently, we presented the DirectMS1 method of ultrafast proteome-wide analysis based on
minute-long LC gradients and MS1-only mass spectra acquisition. Currently, the method …

Hepatic lipid metabolism is highly dynamic, and disruption of several circadian
transcriptional regulators results in hepatic steatosis. This includes genetic disruption of the …

In large‐scale quantitative mass spectrometry (MS)‐based phosphoproteomics, isobaric
labeling with tandem mass tags (TMTs) coupled with offline high‐pH reversed‐phase …

Robust and efficient enzymes are essential modules for metabolic engineering and synthetic
biology strategies across biological systems to engineer whole-cell biocatalysts. By …

Abstract Transglutaminase 3 (TG3), the autoantigen of dermatitis herpetiformis (DH), is a
calcium dependent enzyme that targets glutamine residues in polypeptides for either …

A current trend in proteomics is to acquire data in a “single-shot” by LC–MS/MS because it
simplifies workflows and promises better throughput and quantitative accuracy than …