Myosin VI (Myo6) is the only minus-end directed nanomotor on actin, allowing it to uniquely
contribute to numerous cellular functions. As for other nanomotors, the proper functioning of …

Comprehensive proteome analysis of rare cell phenotypes remains a significant challenge.
We report a method for low cell number MS-based proteomics using protease digestion of …

Extracellular vesicles (EVs) are important players in melanoma progression, but their use as
clinical biomarkers has been limited by the difficulty of profiling blood-derived EV proteins …

Electrical pulse stimulation (EPS) has proven to be a useful tool to interrogate cell-specific
responses to muscle contraction. In the present study, we aimed to uncover networks of …

Background Asexually developed fungal spores (conidia) are key for the massive
proliferation and dispersal of filamentous fungi. Germination of conidia and subsequent …

Mass spectrometry is a powerful technique for investigating renal pathologies and
identifying biomarkers, and efficient protein extraction from kidney tissue is essential for …

Background Despite therapeutic advances, the prognosis of pancreatic ductal
adenocarcinoma (PDAC) remains extremely poor. Metabolic reprogramming is increasingly …

Background Gallbladder cancer (GBC) is a lethal cancer with a poor prognosis. The lack of
specific and sensitive biomarkers results in delayed diagnosis with most patients presenting …

Microbial communities colonize plant tissues and contribute to host function. How these
communities form and how individual members contribute to shaping the microbial …

Sequential window acquisition of all theoretical mass spectra-mass spectrometry
underpinned by advanced bioinformatics offers a framework for comprehensive analysis of …