Despite recent advances in understanding colorectal tumour biology, there is still a need to
improve the 5-year survival rate of patients with colorectal cancer as approximately 40% of …

Disruption of Mdm2-p53 interaction activates p53 signaling, disrupts the balance
ofantiapoptotic and proapoptotic Bcl-2 family proteins and induces apoptosis in …

Toward developing a model system for investigating the role of the microenvironment in the
radioresistance of glioblastoma (GBM), human glioblastoma stem‐like cells (GSCs) were …

Docetaxel is a useful chemotherapeutic agent for the first-line treatment of hormone-
refractory prostate cancer. Abnormal expression of Bcl-2 is commonly found in cancer cells …

We have previously discovered the naturally occurring antitussive alkaloid noscapine as a
tubulin-binding agent that attenuates microtubule dynamics and arrests mammalian cells at …

In recent years, cannabinoids (the active components of Cannabis sativa) and their
derivatives have received considerable interest due to findings that they can affect the …

Purpose: Apoptosis, as a mode of cell death in irradiated cell populations, has been the
subject of literarily hundreds if not thousands of published reports over the past few years …

The unveiling of the heterogeneous nature of cell death modes has compromised the long-
lived consensus that cancer treatment typically kills cancer cells through apoptosis …

According to a widespread model, anti-cancer chemotherapy involves the triggering of tumor
cells to undergo apoptosis, so apoptosis-resistant cells would be recalcitrant to such …

The tumor suppressor protein p53 plays a key role in regulation of negative cellular growth
in response to EGCG. To further explore the role of p53 signaling and elucidate the …