[HTML][HTML] Synthesis, biological evaluation and computer-aided discovery of new thiazolidine-2, 4-dione derivatives as potential antitumor VEGFR-2 inhibitors
In this study, novel VEGFR-2-targeting thiazolidine-2, 4-dione derivatives with potential
anticancer properties were designed and synthesized. The ability of the designed …
anticancer properties were designed and synthesized. The ability of the designed …
Novel promising benzoxazole/benzothiazole‐derived immunomodulatory agents: Design, synthesis, anticancer evaluation, and in silico ADMET analysis
Eleven novel benzoxazole/benzothiazole‐based thalidomide analogs were designed and
synthesized to obtain new effective antitumor immunomodulatory agents. The synthesized …
synthesized to obtain new effective antitumor immunomodulatory agents. The synthesized …
Discovery of new VEGFR-2 inhibitors and apoptosis inducer-based thieno[2,3-d]pyrimidine
Background: VEGFR-2 is a key regulator of cancer cell proliferation, migration and
angiogenesis. Aim: Development of thieno [2, 3-d] pyrimidine derivatives as potential anti …
angiogenesis. Aim: Development of thieno [2, 3-d] pyrimidine derivatives as potential anti …
Anti-breast cancer potential of a new xanthine derivative: in silico, antiproliferative, selectivity, VEGFR-2 inhibition, apoptosis induction and migration inhibition studies
Background The overexpression of VEGFR-2 receptors in breast cancer provides a valuable
approach to anticancer strategies. Targeting VEGFR-2, a new semisynthetic compound (T-1 …
approach to anticancer strategies. Targeting VEGFR-2, a new semisynthetic compound (T-1 …
New theobromine derivatives inhibiting VEGFR-2: design, synthesis, antiproliferative, docking and molecular dynamics simulations
HA Mahdy, H Elkady, MS Taghour… - Future Medicinal …, 2023 - Taylor & Francis
Background: VEGFR-2 is one of the most effective targets in cancer treatment. Aim: The
design and semi-synthesis of new theobromine derivatives as potential VEGFR-2 inhibitors …
design and semi-synthesis of new theobromine derivatives as potential VEGFR-2 inhibitors …
[HTML][HTML] Identification of new theobromine-based derivatives as potent VEGFR-2 inhibitors: design, semi-synthesis, biological evaluation, and in silico studies
This study aimed to design anticancer theobromine derivatives inhibiting VEGFR-2. The new
compounds were tested in vitro to evaluate their effectiveness against MCF-7 and HepG2 …
compounds were tested in vitro to evaluate their effectiveness against MCF-7 and HepG2 …
New thiazolidine-2, 4-diones as effective anti-proliferative and anti-VEGFR-2 agents: Design, synthesis, in vitro, docking, MD simulations, DFT, ADMET, and toxicity …
Abstract Novel thiazolidine-2, 4-dione derivatives, 11a-g, were designed, and synthesized
targeting the VEGFR-2 protein. The in vitro studies indicated the abilities of the synthesized …
targeting the VEGFR-2 protein. The in vitro studies indicated the abilities of the synthesized …
[HTML][HTML] Aryl hydrocarbon receptor as an anticancer target: An overview of ten years odyssey
Aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor belonging to the
basic helix–loop–helix (bHLH)/per-Arnt-sim (PAS) superfamily, is traditionally known to …
basic helix–loop–helix (bHLH)/per-Arnt-sim (PAS) superfamily, is traditionally known to …
A Theobromine Derivative with Anticancer Properties Targeting VEGFR‐2: Semisynthesis, in silico and in vitro Studies
A computer‐assisted drug design (CADD) approach was utilized to design a new acetamido‐
N‐(para‐fluorophenyl) benzamide) derivative of the naturally occurring alkaloid …
N‐(para‐fluorophenyl) benzamide) derivative of the naturally occurring alkaloid …
[HTML][HTML] Design, synthesis, anti-proliferative evaluation, docking, and MD simulation studies of new thieno [2, 3-d] pyrimidines targeting VEGFR-2
In this work, new thieno [2, 3-d] pyrimidine-derived compounds possessing potential
anticancer activities were designed and synthesized to target VEGFR-2. The thieno [2, 3-d] …
anticancer activities were designed and synthesized to target VEGFR-2. The thieno [2, 3-d] …