Most of the genetic information has been lost or transferred to the nucleus during the
evolution of mitochondria. Nevertheless, mitochondria have retained their own genome that …

Mitochondrial DNA copy number (mtDNA-CN) is a biomarker of mitochondrial function and
levels of mtDNA-CN have been reproducibly associated with overall mortality and a number …

Mitochondrial dysfunction is pervasive in human pathologies such as neurodegeneration,
diabetes, cancer, and pathogen infections as well as during normal aging. Cells sense and …

Regenerative stem cell–like memory (TSCM) CD8+ T cells persist longer and produce
stronger effector functions. We found that MEK1/2 inhibition (MEKi) induces TSCM that have …

CD8+ T cells undergo major metabolic changes upon activation, but how metabolism
influences the establishment of long-lived memory T cells after infection remains a key …

There is growing scientific interest to develop scalable biological measures that capture
mitochondrial (dys) function. Mitochondria have their own genome, the mitochondrial DNA …

Cristae, the organized invaginations of the mitochondrial inner membrane, respond
structurally to the energetic demands of the cell. The mechanism by which these dynamic …

TLR agonists initiate a rapid activation program in dendritic cells (DCs) that requires support
from metabolic and bioenergetic resources. We found previously that TLR signaling …

Mitochondrial dysfunction is central to numerous diseases of oxidative stress. Changes in
mitochondrial DNA (MtDNA) content, often measured as mitochondrial genome to nuclear …

INTRODUCTION Mammalian gene expression is tightly controlled through the interplay
between the RNA and protein life cycles. Although studies of individual genes have shown …