[HTML][HTML] An update on Sec61 channel functions, mechanisms, and related diseases
The membrane of the endoplasmic reticulum (ER) of nucleated human cells harbors the
protein translocon, which facilitates membrane integration or translocation of almost every …
protein translocon, which facilitates membrane integration or translocation of almost every …
[HTML][HTML] Inhibitors of the Sec61 complex and novel high throughput screening strategies to target the protein translocation pathway
E Pauwels, R Schülein, K Vermeire - International journal of molecular …, 2021 - mdpi.com
Proteins targeted to the secretory pathway start their intracellular journey by being
transported across biological membranes such as the endoplasmic reticulum (ER). A central …
transported across biological membranes such as the endoplasmic reticulum (ER). A central …
hS nd2 protein represents an alternative targeting factor to the endoplasmic reticulum in human cells
S Haßdenteufel, M Sicking, S Schorr, N Aviram… - FEBS …, 2017 - Wiley Online Library
Recently, understanding of protein targeting to the endoplasmic reticulum (ER) was
expanded by the discovery of multiple pathways that function in parallel to the signal …
expanded by the discovery of multiple pathways that function in parallel to the signal …
Protein transport into the human endoplasmic reticulum
Protein transport into the endoplasmic reticulum (ER) is essential for all eukaryotic cells and
evolutionary related to protein transport into and across the cytoplasmic membrane of …
evolutionary related to protein transport into and across the cytoplasmic membrane of …
[HTML][HTML] Inhibitors of protein translocation across membranes of the secretory pathway: novel antimicrobial and anticancer agents
V Van Puyenbroeck, K Vermeire - Cellular and Molecular Life Sciences, 2018 - Springer
Proteins routed to the secretory pathway start their journey by being transported across
biological membranes, such as the endoplasmic reticulum. The essential nature of this …
biological membranes, such as the endoplasmic reticulum. The essential nature of this …
[HTML][HTML] The molecular biodiversity of protein targeting and protein transport related to the endoplasmic reticulum
A Tirincsi, M Sicking, D Hadzibeganovic… - International journal of …, 2021 - mdpi.com
Looking at the variety of the thousands of different polypeptides that have been focused on
in the research on the endoplasmic reticulum from the last five decades taught us one …
in the research on the endoplasmic reticulum from the last five decades taught us one …
[HTML][HTML] WRB and CAML are necessary and sufficient to mediate tail-anchored protein targeting to the ER membrane
F Vilardi, M Stephan, A Clancy, A Janshoff… - PloS one, 2014 - journals.plos.org
Tail-Anchored (TA) proteins are inserted into the endoplasmic reticulum (ER) membrane of
yeast cells via the posttranslational Guided Entry of Tail-Anchored protein (GET) pathway …
yeast cells via the posttranslational Guided Entry of Tail-Anchored protein (GET) pathway …
[HTML][HTML] Signal peptide features determining the substrate specificities of targeting and translocation components in human ER protein import
In human cells, approximately 30% of all polypeptides enter the secretory pathway at the
level of the endoplasmic reticulum (ER). This process involves cleavable amino-terminal …
level of the endoplasmic reticulum (ER). This process involves cleavable amino-terminal …
TRC40 can deliver short secretory proteins to the Sec61 translocon
N Johnson, F Vilardi, S Lang, P Leznicki… - Journal of cell …, 2012 - journals.biologists.com
Whilst the co-translational translocation of nascent proteins across the mammalian
endoplasmic reticulum (ER) is well defined, the capacity of this organelle for post …
endoplasmic reticulum (ER) is well defined, the capacity of this organelle for post …
Localization of mRNAs to the endoplasmic reticulum
XA Cui, AF Palazzo - Wiley Interdisciplinary Reviews: RNA, 2014 - Wiley Online Library
Almost all cells use mRNA localization to establish spatial control of protein synthesis. One
of the best‐studied examples is the targeting and anchoring of mRNAs encoding secreted …
of the best‐studied examples is the targeting and anchoring of mRNAs encoding secreted …