Loss of functional β-cell mass is the key mechanism leading to the two main forms of
diabetes mellitus—type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) …

For much of the last century, our knowledge regarding the pancreas in type 1 and type 2
diabetes was largely derived from autopsy studies of individuals with these disorders or …

Abstract Purpose of Review To discuss the current understanding of “β cell identity” and
factors underlying altered identity of pancreatic β cells in diabetes, especially in humans …

We review the current knowledge of pancreas pathology in type 1 diabetes. During the last
two decades, dedicated efforts toward the recovery of pancreas from deceased patients with …

Background T1D is an autoimmune disease in which pancreatic islets of Langerhans are
infiltrated by immune cells resulting in the specific destruction of insulin-producing islet beta …

Beta-cell destruction in type 1 diabetes (T1D) results from the combined effect of
inflammation and recurrent autoimmunity. In response to inflammatory signals, beta-cells …

Highlights•Clinical studies claimed islet amyloidosis as a histopathological feature of
diabetes.•Existing treatment strategies are restricted to blood glucose control only.•Micelles …

Painful peripheral neuropathy affects millions of people worldwide. Peripheral neuropathy
develops in patients with various diseases, including rare familial or acquired amyloid …

Islet amyloid polypeptide (IAPP or amylin) is a hormone co‐secreted with insulin by
pancreatic β‐cells and is the major component of islet amyloid. Islet amyloid is found in the …

Introduction There are no validated clinical or laboratory biomarkers to identify and
differentiate endotypes of type 1 diabetes (T1D) or the risk of progression to chronic …