Since their earliest days, humans have been struggling with infectious diseases. Caused by
viruses, bacteria, protozoa, or even higher organisms like worms, these diseases depend …

Intermittent preventive treatment (IPT) with sulphadoxine-pyrimethamine in vulnerable
populations reduces malaria morbidity in Africa, but resistance mutations in the parasite …

We assessed Plasmodium falciparum drug resistance markers in parasites collected in
2012, 2013, and 2015 at 3 sites in Uganda. The prevalence and frequency of parasites with …

Abstract The Kaplan–Meier (K–M) method is currently the preferred approach to derive an
efficacy estimate from anti-malarial trial data. In this approach event times are assumed to be …

Antimalarial drug resistance is a major constraint for malaria control and elimination efforts.
Artemisinin-based combination therapy is now the mainstay for malaria treatment. However …

Many standard-textbook population-genetic results apply to a wide range of species.
Sometimes, however, population-genetic models and principles need to be tailored to a …

Background Altered sensitivity to multiple antimalarial drugs is mediated by polymorphisms
in pfmdr1, which encodes the Plasmodium falciparum multidrug resistance transporter. In …

Background The UN's Sustainable Development Goals are devoted to eradicate a range of
infectious diseases to achieve global well-being. These efforts require monitoring disease …

Abstract Background. In 2007, Malawi replaced sulfadoxine-pyrimethamine (SP) with an
artemisinin-based combination therapy as the first-line treatment for uncomplicated …

The introduction of genomic methods facilitated standardized molecular disease
surveillance. For instance, SNP barcodes in P. vivax and P. falciparum malaria allows the …