In the cornea, resident immune cells are in close proximity to sensory nerves, consistent with
their important roles in the maintenance of nerves in both homeostasis and inflammation …

The cornea is the most densely innervated and sensitive tissue in the body. The cornea is
exclusively innervated by C-and A-delta fibers, including mechano-nociceptors that are …

A grade 3 burn is a nonstatic fatal injury, which can lead to complete damage to the skin
structure, accompanied by a series of symptoms such as persistent inflammation, pain …

As the cornea is densely innervated, its nerves are integral not only to its structure but also to
its pathophysiology. Corneal integrity depends on a protective tear film that is maintained by …

Substance P (SP) is a tachykinin expressed by various cells in the nervous and immune
systems. SP is predominantly released by neurons and exerts its biological and …

Corneal nerves are instrumental to maintain cornea integrity through regulation of key
physiological functions such as tear secretion, blink reflex, and neuropeptide turnover …

The innate immune response is the main pathophysiological process of ocular surface
diseases exposed to multiple environmental stresses. The epithelium is central to the innate …

Background Dry eye disease (DED) is a multifactorial disease of the ocular surface
accompanied by neurosensory abnormalities. Here, we evaluated the effectiveness of …

BACKGROUND Oxidative stress results in the production of excess reactive oxygen species
(ROS) and triggers hippocampal neuronal damage as well as occupies a key role in the …

Persistent ocular pain caused by corneal inflammation and/or nerve injury is accompanied
by significant alterations along the pain axis. Both primary sensory neurons in the trigeminal …