Metastasis formation is the major cause of death in most patients with cancer. Despite
extensive research, targeting metastatic seeding and colonization is still an unresolved …

Metabolism rewiring is an important hallmark of cancers. Being one of the most abundant
free amino acids in the human blood, glutamine supports bioenergetics and biosynthesis …

Simple Summary L-asparaginase (L-ASNase) therapy is key for achieving the very high cure
rate of pediatric acute lymphoblastic leukemia (ALL), yet its use is mostly confined to this …

Asparagine Synthetase (ASNS) catalyzes the synthesis of the non-essential amino acid
asparagine (Asn) from aspartate (Asp) and glutamine (Gln). ASNS expression is highly …

While hundreds of consistently altered metabolic genes had been identified in
hepatocellular carcinoma (HCC), the prognostic role of them remains to be further …

Hepatocellular carcinoma (HCC) is one of the primary liver malignancies with a poor
prognosis. Glutamic-oxaloacetic transaminase 2 (GOT2) is a highly tissue-specific gene in …

Precise isolation and analysis of circulating tumor cells (CTCs) from blood samples offer
considerable potential for cancer research and personalized treatment. Currently, available …

Gastric cancer (GC) is a leading cause of death worldwide. GC is the third-most common
cause of cancer-related death after lung and colorectal cancer. It is also the fifth-most …

Background and Aims Transarterial chemoembolization (TACE) is a standard locoregional
therapy for patients with hepatocellular carcinoma (HCC) patients with a variable overall …

With high prevalence and mortality, together with metabolic reprogramming, colorectal
cancer is a leading cause of cancer-related death. Metabolic reprogramming gives tumors …