Rheumatoid arthritis (RA) is an autoimmune disease that involves multiple joints bilaterally.
It is characterized by an inflammation of the tendon (tenosynovitis) resulting in both cartilage …

The coronavirus disease 2019 pandemic caused by severe acute respiratory syndrome
coronavirus 2 presents with a spectrum of clinical manifestations from asymptomatic or mild …

Background Pneumonia with respiratory failure represents the main cause of death in
COVID-19, where hyper inflammation plays an important role in lung damage. This study …

We have read with interest the excellent review by McGonagle et al. discussing the possible
role of hyperinflammation secondary to macrophage activation syndrome (MAS) or cytokine …

For decades, disintegrin and metalloproteinase 17 (ADAM17) has been the object of deep
investigation. Since its discovery as the tumor necrosis factor convertase, it has been …

Background Pneumonia with severe respiratory failure represents the principal cause of
death in COVID-19, where hyper-inflammation plays an important role in lung damage. An …

The outbreak of coronavirus disease 2019 (COVID‐19) and pandemic, caused by severe
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has become a major concern …

C-reactive protein (CRP) is well-known as a sensitive albeit unspecific biomarker of
inflammation. In most rheumatic conditions, the level of this evolutionarily highly conserved …

Despite the success of targeted therapies in the treatment of inflammatory arthritides, the
lack of predictive biomarkers drives a 'trial and error'approach to treatment allocation …

Interleukin (IL)-6 has been studied since its discovery for its role in health and diseases. It is
one of the most important pro-inflammatory cytokines. IL-6 was reported as an exacerbating …