Skeletal metastases are frequent complications of many cancers, causing bone
complications (fractures, bone pain, disability) that negatively affect the patient's quality of …

Bone metastasis is a major cause of morbidity in persons with cancer. Complications include
pain, impaired mobility, pathological fracture, spinal cord compression, cranial nerve …

Prostate cancer (PC) is the most frequently diagnosed malignancy and a leading cause of
cancer deaths in US men. Many PC cases metastasize and develop resistance to systemic …

While several new therapies are FDA-approved for bone-metastatic prostate cancer (PCa),
patient survival has only improved marginally. Here, we report that chitosan nanoparticle …

In an effort to develop a new therapy for prostate cancer (PCa) bone metastases, we have
created Ad. dcn, a recombinant oncolytic adenovirus carrying the human decorin gene …

In prostate to bone metastases, the “vicious cycle” paradigm has been traditionally used to
illustrate how metastases manipulate the bone forming osteoblasts and resorbing …

Therapeutic agents that inhibit a single target often cannot combat a multifactorial disease
such as cancer. Thus, multi-target inhibitors (MTIs) are needed to circumvent complications …

Abstract Prostate Cancer (PCa) is an important age-related disease being the most common
cancer malignancy and the second leading cause of cancer mortality in men in Western …

There is a trend of increasing prevalence of neuroendocrine tumors (NETs), and the
inherited multiple endocrine neoplasia type 1 (MEN1) syndrome serves as a genetic model …

Inhibition of VEGF signaling can promote lymph node metastasis in preclinical models, but
the mechanism is not fully understood, and successful methods of prevention have not been …