Malaria chemoprevention and drug resistance: a review of the literature and policy implications
CV Plowe - Malaria Journal, 2022 - Springer
Chemoprevention strategies reduce malaria disease and death, but the efficacy of anti-
malarial drugs used for chemoprevention is perennially threatened by drug resistance. This …
malarial drugs used for chemoprevention is perennially threatened by drug resistance. This …
Antimalarial drug resistance in Africa: the calm before the storm?
MD Conrad, PJ Rosenthal - The Lancet Infectious Diseases, 2019 - thelancet.com
Antimalarial drug resistance, in particular resistance to Plasmodium falciparum, challenges
the treatment and control of malaria. In this Review, we summarise evolving patterns of …
the treatment and control of malaria. In this Review, we summarise evolving patterns of …
Prevalence of Plasmodium falciparum haplotypes associated with resistance to sulfadoxine–pyrimethamine and amodiaquine before and after upscaling of seasonal …
KB Beshir, J Muwanguzi, J Nader… - The Lancet Infectious …, 2023 - thelancet.com
Background Seasonal malaria chemoprevention is used in 13 countries in the Sahel region
of Africa to prevent malaria in children younger than 5 years. Resistance of Plasmodium …
of Africa to prevent malaria in children younger than 5 years. Resistance of Plasmodium …
[HTML][HTML] Impact evaluation of seasonal malaria chemoprevention under routine program implementation: a quasi-experimental study in Burkina Faso
T Druetz, N Corneau-Tremblay, T Millogo… - The American journal …, 2018 - ncbi.nlm.nih.gov
Seasonal malaria chemoprevention (SMC) for children< 5 is a strategy that is gaining
popularity in West African countries. Although its efficacy to reduce malaria incidence has …
popularity in West African countries. Although its efficacy to reduce malaria incidence has …
Randomized noninferiority trial of dihydroartemisinin-piperaquine compared with sulfadoxine-pyrimethamine plus amodiaquine for seasonal malaria …
I Zongo, P Milligan, YD Compaore… - Antimicrobial agents …, 2015 - Am Soc Microbiol
The WHO recommends that children living in areas of highly seasonal malaria transmission
in the Sahel subregion should receive seasonal malaria chemoprevention (SMC) with …
in the Sahel subregion should receive seasonal malaria chemoprevention (SMC) with …
Changing antimalarial drug sensitivities in Uganda
SA Rasmussen, FG Ceja, MD Conrad… - Antimicrobial agents …, 2017 - Am Soc Microbiol
Dihydroartemisinin-piperaquine (DP) has demonstrated excellent efficacy for the treatment
and prevention of malaria in Uganda. However, resistance to both components of this …
and prevention of malaria in Uganda. However, resistance to both components of this …
pfmdr1 (Plasmodium falciparum multidrug drug resistance gene 1): a pivotal factor in malaria resistance to artemisinin combination therapies
Introduction: Plasmodium falciparum, the deadly agent of malaria, is notorious for its
capacity to develop drug resistance. Treatment failures of artemisinin therapy regimens …
capacity to develop drug resistance. Treatment failures of artemisinin therapy regimens …
Prospective surveillance study to detect antimalarial drug resistance, gene deletions of diagnostic relevance and genetic diversity of Plasmodium falciparum in …
A Mayor, C da Silva, E Rovira-Vallbona… - BMJ open, 2022 - bmjopen.bmj.com
Introduction Genomic data constitute a valuable adjunct to routine surveillance that can
guide programmatic decisions to reduce the burden of infectious diseases. However …
guide programmatic decisions to reduce the burden of infectious diseases. However …
The duration of chemoprophylaxis against malaria after treatment with artesunate-amodiaquine and artemether-lumefantrine and the effects of pfmdr1 86Y and pfcrt …
Abstract Background The majority of Plasmodium falciparum malaria cases in Africa are
treated with the artemisinin combination therapies artemether-lumefantrine (AL) and …
treated with the artemisinin combination therapies artemether-lumefantrine (AL) and …
Impact of antimalarial treatment and chemoprevention on the drug sensitivity of malaria parasites isolated from Ugandan children
P Tumwebaze, MD Conrad, A Walakira… - Antimicrobial agents …, 2015 - Am Soc Microbiol
Changing treatment practices may be selecting for changes in the drug sensitivity of malaria
parasites. We characterized ex vivo drug sensitivity and parasite polymorphisms associated …
parasites. We characterized ex vivo drug sensitivity and parasite polymorphisms associated …