Acute pancreatitis (AP) is a severe disease with high morbidity and mortality in which
inflammation and coagulation play crucial roles. The development of inflammation leads to …

Pharmacogenomics is a relatively recent yet rapidly expanding field of study examining how
genetic variations influence responses to drugs. Antithrombotic drugs include the …

Aim: To determine the accuracy of international warfarin pharmacogenetic algorithms
developed on large multiethnic cohorts (comprising more than 1000 subjects) to predict …

The individual and ethnic differences of drug effects are very important issues in clinical drug
therapy. They may be caused by genetic variations which mainly come from polymorphisms …

Coumarins are effective drugs for treatment and prevention of thromboembolic events.
However, their use requires a balancing act between the chance of underdosing which …

Warfarin is the most prescribed anticoagulant in Australia. It is used for treatment and
prevention of venous thromboembolism, prevention of thromboembolism in patients with a …

Vitamin K antagonists are highly effective antithrombotic drugs. However, appropriate
dosing is difficult to establish owing to its narrow therapeutic window as well as widespread …

Bovenstaande casus maakt duidelijk dat het klini-sche gevolgen kan hebben als er geen
therapie op maat ('personalised medicine') wordt gegeven op basis van een …