Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage
R Muniyappa, S Lee, H Chen… - American Journal of …, 2008 - journals.physiology.org
Insulin resistance contributes to the pathophysiology of diabetes and is a hallmark of
obesity, metabolic syndrome, and many cardiovascular diseases. Therefore, quantifying …
obesity, metabolic syndrome, and many cardiovascular diseases. Therefore, quantifying …
Diabetes: models, signals, and control
The control of diabetes is an interdisciplinary endeavor, which includes a significant
biomedical engineering component, with traditions of success beginning in the early 1960s …
biomedical engineering component, with traditions of success beginning in the early 1960s …
Partitioning glucose distribution/transport, disposal, and endogenous production during IVGTT
R Hovorka, F Shojaee-Moradie… - American Journal …, 2002 - journals.physiology.org
We have separated the effect of insulin on glucose distribution/transport, glucose disposal,
and endogenous production (EGP) during an intravenous glucose tolerance test (IVGTT) by …
and endogenous production (EGP) during an intravenous glucose tolerance test (IVGTT) by …
The oral minimal model method
The simultaneous assessment of insulin action, secretion, and hepatic extraction is key to
understanding postprandial glucose metabolism in nondiabetic and diabetic humans. We …
understanding postprandial glucose metabolism in nondiabetic and diabetic humans. We …
[HTML][HTML] Beta-cell dysfunction and glucose intolerance: results from the San Antonio metabolism (SAM) study
A Gastaldelli, E Ferrannini, Y Miyazaki, M Matsuda… - Diabetologia, 2004 - Springer
Aims/hypothesis Both insulin resistance and beta-cell dysfunction play a role in the transition
from normal glucose tolerance (NGT) to Type 2 diabetes (T2DM) through impaired glucose …
from normal glucose tolerance (NGT) to Type 2 diabetes (T2DM) through impaired glucose …
Insulin sensitivity from meal tolerance tests in normal subjects: a minimal model index
In this report a new approach is introduced that allows estimation of insulin sensitivity (SI)
from orally ingested glucose during an oral glucose tolerance test (OGTT) or a meal glucose …
from orally ingested glucose during an oral glucose tolerance test (OGTT) or a meal glucose …
First-phase insulin secretion: does it exist in real life? Considerations on shape and function
A Caumo, L Luzi - American Journal of Physiology …, 2004 - journals.physiology.org
To fulfill its preeminent function of regulating glucose metabolism, insulin secretion must not
only be quantitatively appropriate but also have qualitative, dynamic properties that optimize …
only be quantitatively appropriate but also have qualitative, dynamic properties that optimize …
QUICKI is a useful index of insulin sensitivity in subjects with hypertension
H Chen, G Sullivan, LQ Yue, A Katz… - American Journal of …, 2003 - journals.physiology.org
Insulin resistance may link disorders of metabolic homeostasis such as diabetes and obesity
with disorders of hemodynamic homeostasis such as hypertension. Thus it is of interest to …
with disorders of hemodynamic homeostasis such as hypertension. Thus it is of interest to …
Minimal model SGoverestimation and SIunderestimation: improved accuracy by a Bayesian two-compartment model
The intravenous glucose tolerance test (IVGTT) single-compartment minimal model (1CMM)
method has recently been shown to overestimate glucose effectiveness and underestimate …
method has recently been shown to overestimate glucose effectiveness and underestimate …
WinSAAM: a windows-based compartmental modeling system
D Stefanovski, PJ Moate, RC Boston - Metabolism, 2003 - Elsevier
Over the last 50 years, complex, dynamic, compartmental models have been used to
describe and to make predictions on a host of pharmacokinetic, metabolic, and biological …
describe and to make predictions on a host of pharmacokinetic, metabolic, and biological …