[HTML][HTML] The development of molecular biology of osteoporosis

Y Gao, S Patil, J Jia - International journal of molecular sciences, 2021 - mdpi.com
Osteoporosis is one of the major bone disorders that affects both women and men, and
causes bone deterioration and bone strength. Bone remodeling maintains bone mass and …

The mechanism of bone remodeling after bone aging

H Fang, Z Deng, J Liu, S Chen, Z Deng… - Clinical Interventions in …, 2022 - Taylor & Francis
Senescence mainly manifests as a series of degenerative changes in the morphological
structure and function of the body. Osteoporosis is a systemic bone metabolic disease …

Advances in the occurrence and biotherapy of osteoporosis

Z Zou, W Liu, L Cao, Y Liu, T He… - Biochemical Society …, 2020 - portlandpress.com
Osteoporosis (OP) is a bone metabolic disease, is characterized by degeneration of bone
structure and decreased bone mass. It happens in more than 1/3 women and 1/5 men of …

Calvarial versus long bone: implications for tailoring skeletal tissue engineering

D Wang, JR Gilbert, X Zhang, B Zhao… - … Engineering Part B …, 2020 - liebertpub.com
Tissue-engineered graft substitutes have shown great potential to treat large bone defects.
While we usually assume that therapeutic approaches developed for appendicular bone …

[HTML][HTML] Linking the relation between gut microbiota and glucocorticoid-induced osteoporosis

RX Zhou, YW Zhang, MM Cao, CH Liu, YF Rui… - Journal of Bone and …, 2023 - Springer
Osteoporosis (OP) is the most prevalent metabolic bone disease, characterized by the low
bone mass and microarchitectural deterioration of bone tissue. Glucocorticoid (GC) clinically …

[HTML][HTML] Combination therapy of PTH and antiresorptive drugs on osteoporosis: a review of treatment alternatives

C Zhang, C Song - Frontiers in Pharmacology, 2021 - frontiersin.org
Antiresorptive drugs have been widely used for osteoporosis. Intermittent parathyroid
hormone (PTH), an anabolic agent, increases osteoblast production rate and inhibits …

[HTML][HTML] Hepatic osteodystrophy—molecular mechanisms proposed to favor its development

S Ehnert, RH Aspera-Werz, M Ruoß, S Dooley… - International journal of …, 2019 - mdpi.com
Almost all patients with chronic liver diseases (CLD) show altered bone metabolism.
Depending on the etiology, this manifests in a severe osteoporosis in up to 75% of the …

[HTML][HTML] Metabolic bone diseases and new drug developments

V Natesan, SJ Kim - Biomolecules & therapeutics, 2022 - ncbi.nlm.nih.gov
Metabolic bone diseases are serious health issues worldwide, since several million
individuals over the age of 50 are at risk of bone damage and should be worried about their …

[HTML][HTML] Learning from monocyte-macrophage fusion and multinucleation: potential therapeutic targets for osteoporosis and rheumatoid arthritis

L Gambari, F Grassi, L Roseti, B Grigolo… - International Journal of …, 2020 - mdpi.com
Excessive bone resorption by osteoclasts (OCs) covers an essential role in developing bone
diseases, such as osteoporosis (OP) and rheumatoid arthritis (RA). Monocytes or …

[HTML][HTML] Inflammasomes and the IL-1 family in bone homeostasis and disease

HW Tseng, SG Samuel, K Schroder… - Current Osteoporosis …, 2022 - Springer
Abstract Purpose of Review Inflammasomes are multimeric protein structures with crucial
roles in host responses against infections and injuries. The importance of inflammasome …