The vaginal microbiota, human papillomavirus infection and cervical intraepithelial neoplasia: what do we know and where are we going next?

A Mitra, DA MacIntyre, JR Marchesi, YS Lee… - Microbiome, 2016 - Springer
The vaginal microbiota plays a significant role in health and disease of the female
reproductive tract. Next-generation sequencing techniques based upon the analysis of …

Vaginal dysbiosis and the risk of human papillomavirus and cervical cancer: systematic review and meta-analysis

N Brusselaers, S Shrestha, J Van De Wijgert… - American journal of …, 2019 - Elsevier
Objective The vaginal microbiota proposedly influence the association between human
papillomavirus and cervical cancer. Our aim was to assess whether vaginal dysbiosis affects …

Cervical intraepithelial neoplasia disease progression is associated with increased vaginal microbiome diversity

A Mitra, DA MacIntyre, YS Lee, A Smith, JR Marchesi… - Scientific reports, 2015 - nature.com
Persistent infection with oncogenic Human Papillomavirus (HPV) is necessary for cervical
carcinogenesis. Although evidence suggests that the vaginal microbiome plays a functional …

The role of probiotics in vaginal health

Z Mei, D Li - Frontiers in cellular and infection microbiology, 2022 - frontiersin.org
Probiotics have been widely used in the treatment of intestinal diseases, but the effect of
probiotics on female reproductive tract health is still controversial. Lactobacillus is the most …

The role of the cervicovaginal microbiome on the genesis and as a biomarker of premalignant cervical intraepithelial neoplasia and invasive cervical cancer

G Curty, PS de Carvalho, MA Soares - International journal of molecular …, 2019 - mdpi.com
The microbiome is able to modulate immune responses, alter the physiology of the human
organism, and increase the risk of viral infections and development of diseases such as …

Does the vaginal microbiota play a role in the development of cervical cancer?

M Kyrgiou, A Mitra, AB Moscicki - Translational Research, 2017 - Elsevier
Persistent infection with oncogenic human papillomavirus (HPV) is necessary but not
sufficient for the development of cervical cancer. The factors promoting persistence as well …

The influence of diet on anti-cancer immune responsiveness

L Soldati, L Di Renzo, E Jirillo, PA Ascierto… - Journal of translational …, 2018 - Springer
Immunotherapy has matured into standard treatment for several cancers, but much remains
to be done to extend the reach of its effectiveness particularly to cancers that are resistant …

Postbiotic metabolites produced by Lactobacillus plantarum strains exert selective cytotoxicity effects on cancer cells

LO Chuah, HL Foo, TC Loh… - … and alternative medicine, 2019 - Springer
Background Lactobacillus plantarum, a major species of Lactic Acid Bacteria (LAB), are
capable of producing postbiotic metabolites (PM) with prominent probiotic effects that have …

Interplay between the temporal dynamics of the vaginal microbiota and human papillomavirus detection

RM Brotman, MD Shardell, P Gajer… - The Journal of …, 2014 - academic.oup.com
Background. We sought to describe the temporal relationship between vaginal microbiota
and human papillomavirus (HPV) detection. Methods. Thirty-two reproductive-age women …

The interplay between human papillomavirus and vaginal microbiota in cervical cancer development

K Sharifian, Z Shoja, S Jalilvand - Virology Journal, 2023 - Springer
Over the past few decades, we have grown accustomed to the idea that human
papillomavirus can cause tumors. The genetic and environmental factors that make the …