Curative cancer therapy remains a major challenge particularly in cancers displaying
multidrug resistance (MDR). The MDR phenotype is characterized by cross-resistance to a …

Ovarian cancer is the seventh most common gynaecologic malignancy seen in women.
Majority of the patients with ovarian cancer are diagnosed at the advanced stage making …

Simple Summary Accumulation of excess fluid in the abdomen typically indicates abnormal
function or disease, such as cancer, in the underlying tissues. This accumulation of fluid, or …

Malignant ascites constitute a unique tumor microenvironment providing a physical structure
for the accumulation of cellular and acellular components. Ascites is initiated and …

The cancer stem cell (CSC) model proposes that tumor development and progression are
fueled and sustained by undifferentiated cancer cells, endowed with self-renewal and tumor …

Growth factors in tumor environments are regulators of cell survival and metastasis. Here,
we reveal the dichotomy between TGF-β superfamily growth factors BMP and TGF-β/activin …

Ovarian cancer (OC) has a specific type of metastasis, via transcoelomic, and most of the
patients are diagnosed at advanced stages with multiple tumors spread within the peritoneal …

Epithelial ovarian cancer (EOC) is a leading cause of cancer-related death in women. Late-
stage diagnosis with significant tumor burden, accompanied by recurrence and …

Myeloid-derived suppressor cells (MDSC) play a key immunosuppressive role in various
types of cancer, including ovarian cancer (OC). In this study, we characterized CD14+ HLA …

Resistance to platinum-based chemotherapy is a major clinical challenge in ovarian cancer,
contributing to the high mortality-to-incidence ratio. Management of the platinum-resistant …