Deregulated transcription factors and poor clinical outcomes in cancer patients

Y Li, AS Azmi, RM Mohammad - Seminars in cancer biology, 2022 - Elsevier
Transcription factors are a group of proteins, which possess DNA-binding domains, bind to
DNA strands of promoters or enhancers, and initiate transcription of genes with cooperation …

[HTML][HTML] The role of KLF transcription factor in the regulation of cancer progression

ZY Li, YX Zhu, JR Chen, X Chang, ZZ Xie - Biomedicine & …, 2023 - Elsevier
Kruppel-like factors (KLFs) are a family of zinc finger transcription factors that have been
found to play an essential role in the development of various human tissues, including …

[HTML][HTML] Cisplatin-activated ERβ/DCAF8 positive feedback loop induces chemoresistance in non-small cell lung cancer via PTEN/Akt axis

Y Hu, Y Xu, T Zhang, Q Han, L Li, M Liu, N Li… - Drug Resistance …, 2023 - Elsevier
High levels of the estrogen receptor β (ERβ) predict poor prognosis following platinum-
containing adjuvant chemotherapies in patients with non-small cell lung cancer (NSCLC) …

[HTML][HTML] Targeting estrogen metabolism in high-grade serous ovarian cancer shows promise to overcome platinum resistance

N Marolt, R Pavlič, T Kreft, M Gjogorska… - Biomedicine & …, 2024 - Elsevier
The high mortality rate due to chemoresistance in patients with high-grade ovarian cancer
(HGSOC) emphasizes the urgent need to determine optimal treatment strategies for …

[HTML][HTML] CD44 receptor-mediated/reactive oxygen species-sensitive delivery of nanophotosensitizers against cervical cancer cells

J Yoon, H Kim, YIL Jeong, HS Yang - International Journal of Molecular …, 2022 - mdpi.com
Stimulus-sensitive, nanomedicine-based photosensitizer delivery has an opportunity to
target tumor tissues since oxidative stress and the expression of molecular proteins, such as …

[HTML][HTML] The epigenetic regulation of nonhistone proteins by SETD7: New targets in cancer

C Chiang, H Yang, L Zhu, C Chen, C Chen… - Frontiers in …, 2022 - frontiersin.org
Epigenetic modifications are essential mechanism by which to ensure cell homeostasis. One
such modification is lysine methylation of nonhistone proteins by SETD7, a mono …

siRNA-mediated silencing of Nanog reduces stemness properties and increases the sensitivity of HepG2 cells to cisplatin

H Alemohammad, R Motafakkerazad, Z Asadzadeh… - Gene, 2022 - Elsevier
Liver cancer is one of the most lethal cancers having worldwide prevalence. Despite
significant progress in cancer therapy, liver cancer-induced mortality is very high. Nanog, as …

The role of sex and gender in the diagnosis and treatment of lung cancer: the 6th ICAPEM Annual Symposium

N Viñolas, L Mezquita, J Corral, M Cobo… - Clinical and …, 2024 - Springer
The incidence and mortality of lung cancer in women are rising, with both increasing by
124% between 2003 and 2019. The main risk factor for lung cancer is tobacco use, but …

The Role of Long Non-Coding RNF144A-AS1 in Cancer Progression

W Wu, X Li, X Li, J Zhao, Y Gui, Y Luo, H Wang… - Cell Biochemistry and …, 2024 - Springer
RNAs transcribing more than 200 nucleotides without encoding proteins are termed long
non-coding RNAs (LncRNAs). LncRNAs can be used as decoy molecules, signal molecules …

[HTML][HTML] Inducers and Inhibitors of Pyroptotic Death of Granulosa Cells in Models of Premature Ovarian Insufficiency and Polycystic Ovary Syndrome

C Berkel - Reproductive Sciences, 2024 - Springer
Granulosa cells (GCs), the largest cell population and primary source of steroid hormones in
the ovary, are the important somatic ovarian components. They have critical roles in …