AMD3100 is a symmetric bicyclam, prototype non-peptide antagonist of the CXCR4
chemokine receptor. Mutational substitutions at 16 positions located in TM-III,-IV,-V,-VI, and …

4-{[4-({(3 R)-1-Butyl-3-[(R)-cyclohexyl (hydroxy) methyl]-2, 5dioxo-1, 4, 9-triazaspiro [5.5]
undec-9-yl} methyl) phenyl] oxy} benzoic acid hydrochloride (873140) is a potent …

Eosinophilic leukocytes accumulate in high numbers in the lungs of asthmatic patients, and
are believed to be important in the pathogenisis of asthma. A potent eosinophil …

The physiological roles of chemokine receptors have expanded beyond host defense and
now represent important targets for intervention in several disease indications. Chemokine …

I-TAC, IP10, and Mig are interferon-γ inducible CXC chemokines that share the same G-
protein-coupled receptor CXCR3, which is preferentially expressed on Th1 lymphocytes. We …

Huey Lewis and the News summed it up nicely in their 1980s hit record:'I want a new drug,
one that won't make me sick, one that won't make me crash my car, or make me feel three …

Cytokines play a critical role in orchestrating and perpetuating inflammation in asthmatic
airways and several specific cytokine and chemokine inhibitors are now in development for …

Activated platelets release micromolar concentrations of the chemokine CXCL4/Platelet
Factor-4. Deposition of CXCL4 onto the vascular endothelium is involved in atherosclerosis …

Studies showing that neurotrophin binding to p75NTR can promote cell survival in the
absence of Trk (tropomyosin-related kinase) receptors, together with recent structural data …

ABSTRACT CCL11, CCL24, and CCL26 are chemokines involved in the recruitment of
eosinophils into tissues and mainly activate CCR3. Whereas the genomic or …