Exacerbations of asthma and chronic obstructive pulmonary disease (COPD): focus on virus induced exacerbations
Asthma and chronic obstructive pulmonary disease (COPD) are the 2 most prevalent chronic
airway diseases. Much of the morbidity, mortality and health care costs of the diseases are …
airway diseases. Much of the morbidity, mortality and health care costs of the diseases are …
Allosteric modulation of G-protein coupled receptors
AA Jensen, TA Spalding - European journal of pharmaceutical sciences, 2004 - Elsevier
The superfamily of G-protein coupled receptors (GPCRs) has more than 1000 members and
is the largest family of proteins in the body. GPCRs mediate signalling of stimuli as diverse …
is the largest family of proteins in the body. GPCRs mediate signalling of stimuli as diverse …
Strategies for the identification of allosteric modulators of G-protein-coupled receptors
NT Burford, J Watson, R Bertekap, A Alt - Biochemical pharmacology, 2011 - Elsevier
Once considered a pharmacological curiosity, allosteric modulation of seven
transmembrane domain G-protein-coupled receptors (GPCRs) has emerged as a potentially …
transmembrane domain G-protein-coupled receptors (GPCRs) has emerged as a potentially …
Chemokine receptor antagonists: part 2
Background: The first part of this two-part review discussed approaches to generating
antagonists for some of the CC chemokine receptors, including CCR1, CCR2, CCR3, and …
antagonists for some of the CC chemokine receptors, including CCR1, CCR2, CCR3, and …
Docking studies for multi-target drugs
The most basic principle of drug action is found in the lock and key model, where the highest
possible affinity for a target that also avoids side effects is desired. For many years this was …
possible affinity for a target that also avoids side effects is desired. For many years this was …
Blockade of autocrine CCL5 responses inhibits Zika virus persistence and spread in human brain microvascular endothelial cells
MC Mladinich, JN Conde, WR Schutt, SY Sohn… - MBio, 2021 - Am Soc Microbiol
Zika virus (ZIKV) is a neurovirulent flavivirus that uniquely causes fetal microcephaly, is
sexually transmitted, and persists in patients for up to 6 months. ZIKV persistently infects …
sexually transmitted, and persists in patients for up to 6 months. ZIKV persistently infects …
[HTML][HTML] Identification of the first nonpeptidergic inverse agonist for a constitutively active viral-encoded G protein-coupled receptor
P Casarosa, WM Menge, R Minisini, C Otto… - Journal of Biological …, 2003 - ASBMB
Human cytomegalovirus (HCMV) encodes a G protein-coupled receptor (GPCR), named
US28, which shows homology to chemokine receptors and binds several chemokines with …
US28, which shows homology to chemokine receptors and binds several chemokines with …
Activation of CXCR7 receptor promotes oligodendroglial cell maturation
P Göttle, D Kremer, S Jander, V Ödemis… - Annals of …, 2010 - Wiley Online Library
Objective: Differentiation of oligodendroglial precursor cells is crucial for central nervous
system (re) myelination and is influenced by multiple extrinsic and intrinsic factors …
system (re) myelination and is influenced by multiple extrinsic and intrinsic factors …
Molecular characterization of the chemokine receptor CXCR3: evidence for the involvement of distinct extracellular domains in a multi‐step model of ligand binding …
G Xanthou, TJ Williams… - European journal of …, 2003 - Wiley Online Library
CXCR3 is a chemokine receptor predominantly expressed on T lymphocytes, and binds the
chemokines CXCL9 (Mig), CXCL10 (IP‐10) and CXCL11 (I‐TAC). Here, we have …
chemokines CXCL9 (Mig), CXCL10 (IP‐10) and CXCL11 (I‐TAC). Here, we have …
Cytokine modulators as novel therapies for airway disease
PJ Barnes - European Respiratory Journal, 2001 - Eur Respiratory Soc
Cytokines play a critical role in orchestrating and perpetuating inflammation in asthma and
chronic obstructive pulmonary disease (COPD), and several specific cytokine and …
chronic obstructive pulmonary disease (COPD), and several specific cytokine and …