The chemokine receptor CCR3 is believed to play a role in the development of allergic
diseases such as asthma, atopic dermatitis, and allergic rhinitis. Despite the conflicting …

There are some 850 human G protein-coupled receptors (GPCRs) currently known
(http://bioinformatics2. biol. uoa. gr), making this the most abundant family of well …

The human chemokine system comprises 19 seven-transmembrane helix (7TM) receptors
and 45 endogenous chemokines that often interact with each other in a promiscuous …

The chemokine receptor CX3CR1 has been implicated as an attractive therapeutic target in
several diseases, including atherosclerosis and diabetes. However, there has been a lack of …

Over the last decade there has been an intense interest in the potential role of cytokines and
chemokines as important mediators in various atopic diseases, including asthma and the …

Shikonin is a chemically characterized component of traditional Chinese herbal medicine
and has been shown to possess antiinflammatory activities. We ascertained that shikonin …

Background and purpose: The chemokine receptor CCR1 is a potential target for the
treatment of rheumatoid arthritis. To explore the impact of CCR1 blockade in experimental …

The eosinophil was first named by the brilliant German scientist Paul Ehrlich in 1879, while
he was experimenting with aniline dyes to stain blood cells and tissues. He also discovered …

The G-protein coupled receptor CCR5 is the main co-receptor for macrophage-tropic HIV-1
strains. I have built a structural model of the chemokine receptor CCR5 and used it to …

The chemokine family constitutes a group of specialized cytokines, the primary function of
which is to regulate the trafficking of leucocytes. All family members are small secreted …