Targeting SELPLG/P‐selectin glycoprotein ligand 1 in preclinical ARDS: Genetic and epigenetic regulation of the SELPLG promoter

X Sun, S Sammani, M Hufford, BL Sun… - Pulmonary …, 2023 - Wiley Online Library
We previously identified a missense single nucleotide polymorphism rs2228315 (G> A,
Met62Ile) in the selectin‐P‐ligand gene (SELPLG), encoding P‐selectin glycoprotein ligand …

Who is who within the universe of TREM-like transcripts (TREML)?

MV Ertel, ABA da Silva, DF de Sousa, CJ Dos Santos… - Life Sciences, 2024 - Elsevier
Abstract The Triggering Receptor Expressed on Myeloid Cells (TREM) family of receptors
plays a crucial role in the immune response across various species. Particularly, TREM-1 …

Cardiac megakaryocytes in SARS‐CoV‐2‐positive autopsies

KL Gawelek, R Padera, J Connors, GS Pinkus… - …, 2022 - Wiley Online Library
Thromboembolic phenomena are an important complication of infection by severe acute
respiratory coronavirus 2 (SARS‐CoV‐2). Increasing focus on the management of the …

Megakaryocytes in pulmonary diseases

DY Huang, GM Wang, ZR Ke, Y Zhou, HH Yang, TL Ma… - Life Sciences, 2022 - Elsevier
Megakaryocytes (MKs) are typical cellular components in the circulating blood flowing from
the heart into the lungs. Physiologically, MKs function as an important regulator of platelet …

Bisphenol AF elevates procoagulant platelets by inducing necroptosis via RIPK1-inflammasome axis

GJ Vishalakshi, M Hemshekhar, VD Sandesha… - Toxicology, 2021 - Elsevier
Bisphenol AF, an analogue of Bisphenol A, is an important raw material used in the
production of plastic and rubber substances like plastic bottles and containers, toys, and …

Nonlinear relationship between platelet count and 30-day in-hospital mortality in ICU acute respiratory failure patients: a multicenter retrospective cohort study

P Zhou, Q Guo, F Wang, L Zhou, H Hu… - European Journal of …, 2024 - Springer
Background Limited evidence exists regarding the link between platelet count and 30-day in-
hospital mortality in acute respiratory failure (ARF) patients. Thus, this study aims to …

Pharmacological management of adult patients with acute respiratory distress syndrome

MG Matera, P Rogliani, A Bianco… - Expert Opinion on …, 2020 - Taylor & Francis
Introduction There is still no definite drug for acute respiratory distress syndrome (ARDS)
that is capable of reducing either short-term or long-term mortality. Therefore, great efforts …

Research progress of megakaryocytes and platelets in lung injury

T Hua, G Zhang, Y Yao, H Jia, W Liu - Annals of Medicine, 2024 - Taylor & Francis
The lung is an important site of extramedullary platelet formation, and megakaryocytes in the
lung participate in immune responses in addition to platelet production. In acute lung injury …

[HTML][HTML] Low-soluble TREM-like transcript-1 levels early after severe burn reflect increased coagulation disorders and predict 30-day mortality

JC Lin, ZR Xu, ZH Chen, XD Chen - Burns, 2021 - Elsevier
Background Patients with severe burns often show systemic coagulation changes in the
early stage and even develop extensive coagulopathy. Previous studies have confirmed that …

Evaluation of postmortem pathological changes in the lung in SARS-CoV-2 RT-PCR positive cases

T Daş, A Buğra, MN Arslan, N Ziyade… - Journal of Surgery and …, 2021 - dergipark.org.tr
Background/Aim: The most common cause of death in COVID-19 is acute respiratory
distress syndrome. Diffuse alveolar damage is the histological characteristic and counterpart …