The kidneys and heart share functions with the common goal of maintaining homeostasis.
When kidney injury occurs, many compounds, the so-called “uremic retention solutes” or …

The importance of phosphate homeostasis in chronic kidney disease (CKD) has been
recognized for decades, but novel insights—which are frequently relevant to everyday …

Emerging evidences demonstrate the involvement of gut microbiota in the progression of
chronic kidney disease (CKD) and CKD-associated complications including cardiovascular …

Disturbances in phosphate homeostasis are common in patients with chronic kidney
disease. As kidney function declines, circulating concentrations of phosphate and the …

Abstract Cardiorenal syndrome type 4 (CRS4) is a common complication of chronic kidney
disease (CKD), but the pathogenic mechanisms remain elusive. Here we report that …

Vascular dysfunction is an essential element found in many cardiovascular pathologies and
in pathologies that have a cardiovascular impact such as chronic kidney disease (CKD) …

Uremic toxins can induce endothelial dysfunction in patients with chronic kidney disease
(CKD). Indeed, the structure of the endothelial monolayer is damaged in CKD, and studies …

Chronic kidney disease (CKD) triggers the risk of developing uremic cardiomyopathy as
characterized by cardiac hypertrophy, fibrosis and functional impairment. Traditionally …

Damage to the intestinal mucosa results in the translocation of microbes from the intestinal
lumen into the circulation. Microbial translocation has been proposed to trigger immune …

Calciprotein particles, nanoscale aggregates of insoluble mineral and binding proteins,
have emerged as potential mediators of phosphate toxicity in patients with Chronic Kidney …