Adenosine triphosphate (ATP) is one of the main biochemical components of the tumor
microenvironment (TME), where it can promote tumor progression or tumor suppression …

The kidneys play a key role in maintaining total body homeostasis. The complexity of this
task is reflected in the unique architecture of the organ. Ureteral obstruction greatly affects …

Due to the aggregation‐caused quenching effect and near‐infrared I poor penetration
capabilities of common fluorescent molecules, their applications in visualized imaging and …

Complex multicellular life in mammals relies on functional cooperation of different organs for
the survival of the whole organism. The kidneys play a critical part in this process through …

Metabolic programming is intricately linked to the anti-tumor properties of T cells. To study
the metabolic pathways associated with increased anti-tumor T cell function, we utilized a …

Metabolic interventions via targeting intratumoral dysregulated metabolism pathways have
shown promise in reinvigorating antitumor immunity. However, approved small molecule …

Whether metabolites derived from injured renal tubular epithelial cells (TECs) participate in
renal fibrosis is poorly explored. After TEC injury, various metabolites are released and …

Background Spinal cord injury (SCI) is an inflammatory condition, and excessive adenosine
triphosphate (ATP) is released into the extracellular space, which can be catabolized into …

Ectonucleotidases are key for purinergic signaling. They control the duration of activity of
purinergic receptor agonists. At the same time, they produce hydrolysis products as …

Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD)
worldwide. SGLT2 inhibitors are clinically effective in halting DKD progression. However, the …