Transforming growth factor-β1 (TGF-β1) signaling in hepatic stellate cells (HSCs) plays a
primary role in liver fibrosis, but the source of TGF-β1 is unclear. Because platelets are rich …

Liver fibrosis is featured by activation of hepatic stellate cells (HSCs) and excessive
accumulation of extracellular matrix (ECM). The Golgi apparatus in HSCs plays a vital role in …

Inflammation occurs in all tissues in response to injury or stress and is the key process
underlying hepatic fibrogenesis. Targeting chronic and uncontrolled inflammation is one …

Nonalcoholic steatohepatitis (NASH) is one of the most common chronic liver diseases in
the world, yet no pharmacotherapies are available. The lack of translational animal models …

Background and Purpose Liver fibrosis is a major cause of liver‐related mortality and, so far,
no effective antifibrotic drug is available. Galunisertib, a TGF‐β receptor type I kinase …

Adult liver regeneration requires induction and suppression of proliferative activity in
multiple types of liver cells. The mechanisms that orchestrate the global changes in gene …

Fibrogenesis is a progressive scarring event resulting from disrupted regular wound healing
due to repeated tissue injury and can end in organ failure, like in liver cirrhosis. The …

Background & Aims Currently most liver fibrosis research is performed in vivo, since suitable
alternative in vitro systems which are able to recapitulate the cellular events leading to liver …

Fibrosis is an important wound‐healing process in injured tissues, but excessive fibrosis is
often observed in patients with chronic inflammation. Although oncostatin M (OSM) has been …

Hepatic stellate cells (HSCs) known as “master producers” and macrophages as “master
regulators”, are the key cell types that strongly contribute to the progression of liver fibrosis …