Background Inadequate pain management after surgery increases the risk of postoperative
complications and may predispose for chronic postsurgical pain. Perioperative ketamine …

Magnesium has been shown to produce an antinociceptive effect on animal models of
neuropathic and inflammatory pain. It has also been shown to exert an analgesic effect on …

Neuronal nitric oxide synthase (nNOS) is a key enzyme for nitric oxide production in
neuronal tissues and contributes to the spinal central sensitization in inflammatory pain …

Nitric oxide (NO) acts as a neurotransmitter or neuromodulator involving in the modulation of
thermal and/or inflammatory hyperalgesia. The neuronal nitric oxide synthase (nNOS) is a …

BACKGROUND: The involvement of the l-arginine/nitric oxide (NO)/cyclic guanosine
monophosphate (cGMP) pathway in antinociception has been implicated as a molecular …

Clonidine, an alpha-2 adrenergic agonist, is an extremely potent antinociceptive agent.
However, the therapeutic utility of systemic clonidine for the treatment of pain is limited by …

Objectives The main purpose of this study was to assess the role of l-arginine/SNAP/NO/
cGMP/KATP channel pathway in analgesic effects of α-terpineol in mice. Methods Male …

Background Sitagliptin is an antidiabetic drug that inhibits dipeptidyl peptidase-4 enzyme.
This study aimed to investigate the antinociceptive and anti-inflammatory effects of sitagliptin …

Objective (s): Growing evidence demonstrates that L-arginine/NO/cGMP/K ATP channel
pathway has a modulatory role in pain perception. Previous studies have shown that …

IMPLICATIONS: In a model of burn injury followed at 24 h by sepsis (Escherichia coli),
ketamine given immediately after E. coli inoculation significantly increased survival and …