Myelination is an important process in the central nervous system (CNS). Oligodendrocytes
(OLs) extend multiple layers to densely sheath on axons, composing the myelin to achieve …

Glycosaminoglycans (GAGs) are long, linear polysaccharides that are ubiquitously
expressed on the cell surface and in the extracellular matrix of all animal cells. These …

Tissue engineering to replace an injured/defective organ is considered a complex process
by which the required biological functionalities are restored. As an effective strategy to …

Chondroitin sulfate (CS) is the most abundant and widely distributed glycosaminoglycan
(GAG) in the human body. As a component of proteoglycans (PGs) it has numerous roles in …

Alzheimer's disease (AD), a neurodegenerative disorder characterized by progressive
cognitive decline, is the most common form of dementia. Currently, there is no single test that …

Multidrug resistance is still a major obstacle to cancer treatment. The most studies are to
inhibit the activity of the drug transporter P-glycoprotein (P-gp), but the effect is not ideal …

The brain extracellular matrix (ECM) is a highly glycosylated environment and plays
important roles in many processes including cell communication, growth factor binding, and …

Central and peripheral nervous system (CNS/PNS) proteoglycans (PGs) have diverse
functional roles, this study examined how these control cellular behavior and tissue function …

Dysfunction of the central nervous system (CNS) following traumatic brain injuries (TBI),
spinal cord injuries (SCI), or strokes remains challenging to address using existing …

Type IIa receptor tyrosine phosphatases (RPTPs) play pivotal roles in neuronal network
formation. It is emerging that the interactions of RPTPs with glycans, ie, chondroitin sulfate …