Streptomyces are a large and valuable resource of bioactive and complex secondary
metabolites, many of which have important clinical applications. With the advances in high …

Drug discovery is based on bioactivity screening of natural sources, traditionally represented
by bacteria fungi and plants. Bioactive natural products and their secondary metabolites …

Finding faster and simpler ways to screen protein sequence space to enable the
identification of new biocatalysts for asymmetric synthesis remains both a challenge and a …

For over seven decades, bacteria served as a valuable source of bioactive natural products
some of which were eventually developed into drugs to treat infections, cancer and immune …

The rational discovery of new specialized metabolites by genome mining represents a very
promising strategy in the quest for new bioactive molecules. Ribosomally synthesized and …

Covering: up to 2018 Thioester reductase domains catalyze two-and four-electron
reductions to release natural products following assembly on nonribosomal peptide …

Sequencing of Streptomyces genomes has revealed they harbor a high number of
biosynthesis gene cluster (BGC), which uncovered their enormous potentiality to encode …

The harsh climatic conditions of deserts may lead to unique adaptations of microbes, which
could serve as potential sources of new metabolites to cope with environmental stresses …

The marine environment is an excellent resource for natural products with therapeutic
potential. Its microbial inhabitants, often associated with other marine organisms, are …

Streptomyces is the most important bacterial genus for bioactive compound production.
These soil bacteria are characterized by a complex differentiation cycle. Streptomyces is …