New evidence has challenged the outdated dogma that neutrophils are a homogeneous
population of short-lived cells. Although neutrophil subpopulations with distinct functions …

Heterogeneous populations of myeloid regulatory cells (MRC), including monocytes,
macrophages, dendritic cells, and neutrophils, are found in cancer and infectious diseases …

ABSTRACT SIRT3 (sirtuin 3), a mitochondrial protein deacetylase, maintains respiratory
function, but its role in the regulation of innate immune defense is largely unknown. Herein …

After initial infection, the immune response that serves to restrict the invading pathogen
needs to be tightly calibrated in order to avoid collateral immunopathological damage. This …

Elderly individuals are at increased risk of life-threatening pulmonary infections. Neutrophils
are a key determinant of the disease course of pathogen-induced pneumonia. Optimal host …

Francisella tularensis (Ft) causes a frequently fatal, acute necrotic pneumonia in humans
and animals. Following lethal Ft infection in mice, infiltration of the lungs by predominantly …

Abstract β-Thalassemia is associated with several abnormalities of the innate immune
system. Neutrophils in particular are defective, predisposing patients to life-threatening …

Francisella tularensis causes lethal pneumonia following infection of the lungs by targeting
macrophages for intracellular replication; however, macrophages stimulated with interferon …

Despite recent advances in tuberculosis (TB) drug development and availability, successful
antibiotic treatment is challenged by the parallel development of antimicrobial resistance. As …

The lung is under constant pressure to protect the body from invading bacteria. An effective
inflammatory immune response must be tightly orchestrated to ensure complete clearance of …