Mitochondria act as hubs of numerous metabolic pathways. Mitochondrial dysfunctions
contribute to altering the redox balance and predispose to aging and metabolic alterations …

Worldwide, infertility affects between 10 and 15% of reproductive-aged couples. Female
infertility represents an increasing health issue, principally in developing countries, as the …

The NAD+‐dependent sirtuin deacetylase, Sirt1, regulates key transcription factors strongly
implicated in ageing and lifespan. Due to potential confounding effects secondary to loss of …

Abstract Sirtuin-3 (SIRT3), the main deacetylase in the mitochondria, maintains cellular
energy metabolism and redox balance by deacetylating mitochondrial proteins in a NAD+ …

Female reproduction focuses mainly on achieving fully grown follicles and competent
oocytes to be successfully fertilized, as well as on nourishing the developing offspring once …

The oocyte is considered to be the largest cell in mammalian species. Women hoping to
become pregnant face a ticking biological clock. This is becoming increasingly challenging …

Impaired fertility is the major side effect of chemotherapy for female cancer patients,
accumulated evidence indicates this is associated with damage on oocyte quality, but the …

Meiotic divisions in oocytes are extremely asymmetric and require pre-and post-anaphase-
onset phases of spindle migration. The latter induces membrane protrusion that is moulded …

Dynamic epigenetic regulation is critical for proper oogenesis and early embryo
development. During oogenesis, fully grown germinal vesicle oocytes develop to mature …

For fully differentiated, long lived cells the maintenance of protein homeostasis
(proteostasis) becomes a crucial determinant of cellular function and viability. Neurons are …