The therapeutic areas of infectious diseases and oncology have benefited from abundant
scaffold diversity in natural products, able to interact with many specific targets within the cell …

Covering: 2005 to 2007 Natural product and natural product-derived compounds that are
being evaluated in clinical trials or are in registration (as at 31st December 2007) have been …

Leishmaniasis, one of the most neglected tropical diseases (NTDs), is the third most
important vector-borne disease worldwide. This disease has a global impact and severity of …

This review provides an overview of the discovery, structures, and biological activities of
anticancer natural products that act by inhibiting or promoting the assembly of tubulin to …

Cancer represents a serious global health problem, and its incidence and mortality are
rapidly growing worldwide. One of the main causes of the failure of an anticancer treatment …

The World Health Organization has classified the leishmaniasis as a major tropical disease.
An effective vaccine against leishmaniasis is not available and chemotherapy is the only …

Covering: up to 2008 Natural products contain scaffold structures that can be systematically
exploited for the design of combinatorial compound libraries with druglike properties. We …

Alzheimer's disease (AD) is the most common form of neurodegenerative disorders. If more
effective therapies than the ones currently available are not developed that either prevent …

The chemical scaffolds from which screening libraries are built have strong influence on the
libraries' utility for screening campaigns. Here we present analysis of the scaffold …

There are over 750 species of bacteria that inhabit the human oral cavity, but only a small
fraction of those are attributed to causing plaque-related diseases such as caries …