It is well recognized that brains of older people often harbor cerebrovascular disease
pathology including vessel disease and vascular-related tissue injuries and that this is …

With growing and ageing populations, the incidence of dementia is expected to triple
globally by 2050. In the absence of effective drugs to treat or reverse the syndrome, dietary …

Comorbid proteinopathies might influence the clinical course and have implications for
biomarker and therapeutic development. As pure forms of proteinopathies are still observed …

To determine if sex differences in verbal memory in AD are related to differences in extent or
distribution of pathological tau, we studied 275 participants who were amyloid PET positive …

Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is
characterized by altered cellular metabolism in the brain. Several of these alterations have …

Abstract At autopsy, African American decedents often have mixed Alzheimer's and
cerebrovascular brain pathologies including arteriolosclerosis. We applied a novel in-vivo …

The increasingly appreciated prevalence of complicated stressor‐to‐phenotype
associations in human disease requires a greater understanding of how specific stressors …

The results of animal studies and clinical data support the gut microbiota contribution to the
pathogenesis of Alzheimer's disease (AD). The aim of this pilot study was to evaluate the …

Background Understanding the pathological bases underlying the heterogeneity of motor
decline in old age may lead to targeted treatments. We examined whether different brain …

Age is the most robust risk factor for Alzheimer's dementia, however there is little data on the
relation of age to Alzheimer's disease (AD) and other common neuropathologies that …