Atherosclerosis, a chronic inflammatory disease characterized by arterial plaque
accumulation, remains a significant global health challenge. In recent years …

Cardiovascular diseases are severe diseases posing threat to human health because of
their high morbidity and mortality worldwide. The incidence of diabetes mellitus is also …

Background The management of myocardial ischemia–reperfusion injury (MIRI) presents
continuous therapeutic challenges. NAD-dependent deacetylase Sirtuin 6 (Sirt6) plays …

Pyroptotic cell death, an inflammatory form of programmed cell death (PCD), is emerging as
a potential therapeutic opportunity for radiotherapy (RT). RT is commonly used for cancer …

Introduction Ulcerative colitis (UC) is a primary culprit of inflammatory bowel disease that
entails prompt and effective clinical intervention. Remdesivir (RDV), a broad-spectrum …

Background Pulmonary arterial hypertension (PAH) and the consequent right heart
dysfunction persist with high morbidity and mortality, and the mechanisms and …

Diabetic nephropathy (DN) is a complication of diabetes mellitus (DM) and the main cause
of excess mortality in patients with type 2 DM. The pathogenesis and progression of DN are …

Sirtuins (SIRTs) belong to the family of nicotine adenine dinucleotide (NAD+)-dependent
class III histone deacetylases, which come into play in the regulation of epigenetic …

Licorice is a well-known Chinese medicinal plant that is widely used to treat multiple
diseases and process food; however, wild licorice is now facing depletion. Therefore, there …

Edema is one of the most typical symptoms of nephrotic syndrome. Increased vascular
permeability makes a significant contribution to the progression of edema. Yue-bi-tang (YBT) …