[HTML][HTML] Treatment resistance in psychiatry: state of the art and new directions
OD Howes, ME Thase, T Pillinger - Molecular psychiatry, 2022 - nature.com
Abstract Treatment resistance affects 20–60% of patients with psychiatric disorders; and is
associated with increased healthcare burden and costs up to ten-fold higher relative to …
associated with increased healthcare burden and costs up to ten-fold higher relative to …
Efficacy and safety of ketamine vs electroconvulsive therapy among patients with major depressive episode: a systematic review and meta-analysis
Importance Whether ketamine is as effective as electroconvulsive therapy (ECT) among
patients with major depressive episode remains unknown. Objective To systematically …
patients with major depressive episode remains unknown. Objective To systematically …
Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway
R Dang, M Wang, X Li, H Wang, L Liu, Q Wu… - Journal of …, 2022 - Springer
Background The inflammation and oxidative stress (OS) have been considered crucial
components of the pathogenesis of depression. Edaravone (EDA), a free radical scavenger …
components of the pathogenesis of depression. Edaravone (EDA), a free radical scavenger …
[HTML][HTML] The prevalence and national burden of treatment-resistant depression and major depressive disorder in the United States
M Zhdanava, D Pilon, I Ghelerter… - The Journal of …, 2021 - legacy.psychiatrist.com
Objective: Estimates of prevalence and burden of treatment-resistant depression (TRD) vary
widely in the literature. This study evaluated the prevalence and burden of TRD and the …
widely in the literature. This study evaluated the prevalence and burden of TRD and the …
Age, period, and cohort trends in mood disorder indicators and suicide-related outcomes in a nationally representative dataset, 2005–2017.
Abstract Drawing from the National Survey on Drug Use and Health (NSDUH; N= 611,880),
a nationally representative survey of US adolescents and adults, we assess age, period, and …
a nationally representative survey of US adolescents and adults, we assess age, period, and …
Association of efficacy of resistance exercise training with depressive symptoms: meta-analysis and meta-regression analysis of randomized clinical trials
Importance The physical benefits of resistance exercise training (RET) are well documented,
but less is known regarding the association of RET with mental health outcomes. To date, no …
but less is known regarding the association of RET with mental health outcomes. To date, no …
Chronotype, circadian rhythm, and psychiatric disorders: Recent evidence and potential mechanisms
H Zou, H Zhou, R Yan, Z Yao, Q Lu - Frontiers in neuroscience, 2022 - frontiersin.org
The circadian rhythm is crucial for physiological and behavioral functions. Chronotype,
which represents individual preferences for activity and performance, is associated with …
which represents individual preferences for activity and performance, is associated with …
[HTML][HTML] The economic burden of adults with major depressive disorder in the United States (2005 and 2010)
PE Greenberg, AA Fournier, T Sisitsky… - The Journal of …, 2015 - legacy.psychiatrist.com
Background: The economic burden of depression in the United States—including major
depressive disorder (MDD), bipolar disorder, and dysthymia—was estimated at $83.1 billion …
depressive disorder (MDD), bipolar disorder, and dysthymia—was estimated at $83.1 billion …
The excess costs of depression: a systematic review and meta-analysis
H König, HH König, A Konnopka - Epidemiology and psychiatric …, 2020 - cambridge.org
AimsMajor depressive disorders are highly prevalent in the world population, contribute
substantially to the global disease burden and cause high health care expenditures …
substantially to the global disease burden and cause high health care expenditures …
Targeting glutamate signalling in depression: progress and prospects
Major depressive disorder (MDD) is severely disabling, and current treatments have limited
efficacy. The glutamate N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine was …
efficacy. The glutamate N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine was …