An area that has come to be of tremendous interest in tumor research in the last decade is
the role of the microenvironment in the biology of neoplastic diseases. The tumor …

The process of evaluating the efficacy and toxicity of drugs is important in the production of
new drugs to treat diseases. Testing in humans is the most accurate method, but there are …

Background: The tumor three-dimensional (3D) spheroid model in vitro is effective on
detecting malignant cells and tumorigenesis, and assessing drug resistance. Compared with …

Hepatocellular carcinoma (HCC) is the sixth most common cancer and the second leading
cause of cancer worldwide. Despite approvals of several therapeutics to treat advanced …

As three-dimensional cell culture formats gain in popularity, there emerges a need for tools
that produce vast amounts of data on individual cells within the spheroids or organoids …

Simple Summary Tumor stroma is known to significantly influence cancer initiation and
progression. In the last decade, 3D cell cultures have shown potential in modeling the tumor …

Cancer stem cells have been shown to be important in tumorigenesis processes, such as
tumor growth, metastasis, and recurrence. As such, many three-dimensional models have …

Nanogels have piqued the interest of researchers as nanoscopic drug delivery systems,
especially for site-specific or time-controlled delivery of therapeutic mediators. A wide range …

Traumatic skeletal muscle injuries cause irreversible tissue damage and impaired
revascularization. Engineered muscle is promising for enhancing tissue revascularization …

Compared to various traditional 2D approaches, the scaffold‐based 3D tumor models have
emerged as an effective strategy to investigate the complex mechanisms behind cancer …