Molecular mechanisms and treatment strategies for methamphetamine‑induced neurodegeneration, inflammation and neurotoxicity

S Omidvari, Z Azimzadeh, F Rashnoo… - Acta neurobiologiae …, 2023 - ane.pl
Methamphetamine (METH) is a highly addictive psychostimulant known for its profound
impact on the nervous system. Chronic METH use leads to neurotoxicity characterized by …

The common denominators of Parkinson's disease pathogenesis and methamphetamine abuse

B Vincent, M Shukla - Current Neuropharmacology, 2023 - hal.science
The pervasiveness and mortality associated with methamphetamine abuse has doubled
during the past decade suggesting a possible worldwide substance use crisis. Epitomizing …

[HTML][HTML] The gut microbiota as a potential biomarker for methamphetamine use disorder: evidence from two independent datasets

L Liu, Z Deng, W Liu, R Liu, T Ma, Y Zhou… - Frontiers in Cellular …, 2023 - frontiersin.org
Background Methamphetamine use disorder (MUD) poses a considerable public health
threat, and its identification remains challenging due to the subjective nature of the current …

[HTML][HTML] Immunotherapies for the treatment of drug addiction

MK Hossain, M Davidson, E Kypreos, J Feehan… - Vaccines, 2022 - mdpi.com
Substance use disorders (SUD) are a serious public health concern globally. Existing
treatment platforms suffer from a lack of effectiveness. The development of immunotherapies …

[HTML][HTML] Tryptophan and substance abuse: mechanisms and impact

M Davidson, N Rashidi, MK Hossain, A Raza… - International Journal of …, 2023 - mdpi.com
Addiction, the continuous misuse of addictive material, causes long-term dysfunction in the
neurological system. It substantially affects the control strength of reward, memory, and …

[HTML][HTML] Methamphetamine exposure drives cell cycle exit and aberrant differentiation in rat hippocampal-derived neurospheres

S Wang, L Wang, Q Bu, Q Wei, L Jiang, Y Dai… - Frontiers in …, 2023 - frontiersin.org
Introduction: Methamphetamine (METH) abuse by pregnant drug addicts causes toxic effects
on fetal neurodevelopment; however, the mechanism underlying such effect of METH is …

[HTML][HTML] Immunotherapeutic treatment of inflammation in mice exposed to methamphetamine

JM Loftis, S Ramani, EJ Firsick, R Hudson… - Frontiers in …, 2023 - frontiersin.org
Introduction Currently, there are no FDA-approved medications to treat methamphetamine
addiction, including the inflammatory, neurotoxic, and adverse neuropsychiatric effects. We …

[HTML][HTML] Vaccines to Treat Substance Use Disorders: Current Status and Future Directions

T Lu, X Li, W Zheng, C Kuang, B Wu, X Liu, Y Xue… - Pharmaceutics, 2024 - mdpi.com
Addiction, particularly in relation to psychostimulants and opioids, persists as a global health
crisis with profound social and economic ramifications. Traditional interventions, including …

Inhibition of GSDMD-dependent pyroptosis decreased methamphetamine self-administration in rats

Y Shen, X Gong, L Qian, Y Ruan, S Lin, Z Yu… - Brain, Behavior, and …, 2024 - Elsevier
It is widely believed that the activation of the central dopamine (DA) system is crucial to the
rewarding effects of methamphetamine (METH) and to the behavioral outcomes of METH …

Efficacy of probiotic supplements in improving the symptoms of psychosis, anxiety, insomnia, and anorexia due to amphetamine and methamphetamine use: a …

R Badrfam, A Zandifar, A Hajialigol, M Rashidian… - …, 2024 - Springer
Rationale Changes in the density and diversity of gut microbiota in chronic use of
methamphetamine have been mentioned as contributors to psychotic and anxiety …