Pharmacokinetic drug-drug interactions are frequently characterized and quantified by an
AUC ratio (Rauc). The typical value of the AUC ratio in case of cytochrome-mediated …

This M ini R eview is a personal recollection of selected research topics, which the author in
collaboration with colleagues has studied, aiming to improve the predictability of drug …

Cytochrome P450 (P450) is the superfamily of enzymes responsible for biotransformation of
endobiotics and xenobiotics. However, their large isoform multiplicity, inducibility, diverse …

Luther et al Paroxysmal Hypertension associated with Presyncope 719 purely epinephrine
secreting pheochromocytoma and their symptoms and signs were they developed severe …

The activity of CYP1A2, a major drug-metabolizing enzyme, is known to be affected by
various environmental factors. Our study aimed to predict inter-individual variability of …

This phase 1 open‐label, multicenter, 3‐period, fixed‐sequence study evaluated the effect of
multiple doses of vemurafenib on the pharmacokinetics of 1 dose of tizanidine, a probe …

Background and objective We recently discovered that rofecoxib is a potent mechanism-
based inhibitor of CYP1A2. The effect of the widely used cyclo-oxygenase-2 selective non …

Objective To assess the extent of appropriate counseling provided to patients by
pharmacists and nonpharmacists in retail settings regarding herbal dietary supplements for …

In 1982 John Robert Vane shared the Nobel Prize with Sune Bergström and Bengt Ingemar
Samuelsson for 'discoveries concerning prostaglandins and related biologically active …

Objective Our aim was to correlate the in vitro and in vivo CYP1A2 inhibition potential of
tolfenamic acid, an NSAID highly (99.7%) bound to plasma proteins, to study the …